About Tyrosine-protein kinase Fyn
Tyrosine-protein kinase Fyn (FYN) is a protein
from Homo sapiens identified by UniProt accession
P06241, 537 residues long.
MolForge cross-references it against 0 known binders and
522 disease associations.
Target properties
| Protein name | Tyrosine-protein kinase Fyn |
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| UniProt accession | P06241 |
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| Gene | FYN |
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| Organism | Homo sapiens |
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| Length | 537 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (522)
Diseases linked to this target (Open Targets).
- chronic myelogenous leukemia · score 0.60
- cancer · score 0.59
- acute lymphoblastic leukemia · score 0.55
- neurodegenerative disease · score 0.53
- cutaneous Leishmaniasis · score 0.46
- lymphoid leukemia · score 0.45
- electrocardiography · score 0.42
- neoplasm · score 0.42
- multiple myeloma · score 0.41
- hypothyroidism · score 0.40
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P06241-F1 | alphafold | PREDICTED | 80.84 | — |
Amino-acid sequence (537 residues)
MGCVQCKDKE ATKLTEERDG SLNQSSGYRY GTDPTPQHYP SFGVTSIPNY NNFHAAGGQG LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD LSFHKGEKFQ ILNSSEGDWW EARSLTTGET GYIPSNYVAP VDSIQAEEWY FGKLGRKDAE RQLLSFGNPR GTFLIRESET TKGAYSLSIR DWDDMKGDHV KHYKIRKLDN GGYYITTRAQ FETLQQLVQH YSERAAGLCC RLVVPCHKGM PRLTDLSVKT KDVWEIPRES LQLIKRLGNG QFGEVWMGTW NGNTKVAIKT LKPGTMSPES FLEEAQIMKK LKHDKLVQLY AVVSEEPIYI VTEYMNKGSL LDFLKDGEGR ALKLPNLVDM AAQVAAGMAY IERMNYIHRD LRSANILVGN GLICKIADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW SFGILLTELV TKGRVPYPGM NNREVLEQVE RGYRMPCPQD CPISLHELMI HCWKKDPEER PTFEYLQSFL EDYFTATEPQ YQPGENL
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