Terconazole

Azole Antifungal — GENITO URINARY SYSTEM AND SEX HORMONES

Key facts

Terconazole is an ofp drug in the Azole Antifungal class catalogued in DrugCentral. It was first approved by the FDA in 1987. DrugCentral lists 30 molecular targets, including ADRA2C, Pgrmc1 and SIGMAR1. Recorded indications include Candidal vulvovaginitis.

• Approval status: ofp (first approved 1987 by the FDA).
• Drug class: Azole Antifungal.
• Molecular targets: ADRA2C, Pgrmc1, SIGMAR1 and ADRA2A (30 listed in DrugCentral).
• Indications: Candidal vulvovaginitis.
• ATC code: G01AG02 (Triazole derivatives).
• Molecular formula: C26H31Cl2N5O3; molecular weight 532.47 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Candidal vulvovaginitis

Mechanism & targets

• Established pharmacologic class: Azole Antifungal

Molecular targets (30)

Target	Gene	Action	Activity
Alpha-2C adrenergic receptor	ADRA2C	unknown	Ki 7.21
Membrane-associated progesterone receptor component 1	Pgrmc1	unknown	Ki 6.71
Sigma non-opioid intracellular receptor 1	SIGMAR1	unknown	Ki 6.67
Alpha-2A adrenergic receptor	ADRA2A	unknown	Ki 6.43
Heme oxygenase 1	Hmox1	unknown	IC50 6.39
Alpha-2B adrenergic receptor	ADRA2B	unknown	Ki 5.90
Muscarinic acetylcholine receptor M1	CHRM1	unknown	Ki 5.86
D(3) dopamine receptor	DRD3	unknown	Ki 5.80
Muscarinic acetylcholine receptor M4	CHRM4	unknown	Ki 5.72
5-hydroxytryptamine receptor 2A	HTR2A	unknown	Ki 5.63
Arachidonate 15-lipoxygenase	ALOX15	unknown	IC50 5.61
5-hydroxytryptamine receptor 4	HTR4	unknown	Ki 5.61
Lanosterol 14-alpha demethylase	CYP51A1	unknown	IC50 5.52
Muscarinic acetylcholine receptor M3	CHRM3	unknown	Ki 5.51
Muscarinic acetylcholine receptor M5	CHRM5	unknown	Ki 5.50
5-hydroxytryptamine receptor 2C	HTR2C	unknown	Ki 5.44
Sodium/nucleoside cotransporter 1	SLC28A1	unknown	Ki 5.37
Sodium-dependent dopamine transporter	SLC6A3	unknown	Ki 5.36
Muscarinic acetylcholine receptor M2	CHRM2	unknown	Ki 5.34
Heme oxygenase 2	Hmox2	unknown	IC50 5.30

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1987-12-31	FDA	—	JANSSEN PHARMS

ATC classification

ATC code	Therapeutic hierarchy
G01AG02	GENITO URINARY SYSTEM AND SEX HORMONES › GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS › ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS › Triazole derivatives

Chemical structure

• Molecular formula: C₂₆H₃₁Cl₂N₅O₃
• Molecular weight: 532.47 g/mol
• CAS number: 67915-31-5
• InChIKey: BLSQLHNBWJLIBQ-UHFFFAOYSA-N
• PubChem CID: 441383

CC(C)N1CCN(CC1)C1=CC=C(OCC2COC(CN3C=NC=N3)(O2)C2=CC=C(Cl)C=C2Cl)C=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Terconazole used for?

DrugCentral lists the following indications for Terconazole: Candidal vulvovaginitis.

How does Terconazole work?

Its molecular targets in DrugCentral include ADRA2C, Pgrmc1, SIGMAR1 and ADRA2A.

When was Terconazole first approved?

Terconazole was first approved by the FDA in 1987.

What drug class does Terconazole belong to?

Terconazole is in the Azole Antifungal class.

What is the chemical formula of Terconazole?

Terconazole has the molecular formula C26H31Cl2N5O3 and a molecular weight of 532.47 g/mol.

Sources

• DrugCentral drug card 2599 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1714574 — compound record and bioactivity
• PubChem CID 441383 — chemical identifiers
• DrugBank DB00251 — drug record
• FDA UNII 0KJ2VE664U — substance identity
• DailyMed: FDA labels for Terconazole — current prescribing information (label search)
• UniProt P18825 (ADRA2C) — target protein
• UniProt Q99720 (SIGMAR1) — target protein
• UniProt P08913 (ADRA2A) — target protein
• UniProt P18089 (ADRA2B) — target protein
• UniProt P11229 (CHRM1) — target protein
• UniProt P35462 (DRD3) — target protein

How this page is built: methodology · editorial policy & corrections.