About Sodium/nucleoside cotransporter 1
Sodium/nucleoside cotransporter 1 (SLC28A1) is a protein
from Homo sapiens identified by UniProt accession
O00337, 649 residues long.
MolForge cross-references it against 0 known binders and
78 disease associations.
Target properties
| Protein name | Sodium/nucleoside cotransporter 1 |
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| UniProt accession | O00337 |
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| Gene | SLC28A1 |
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| Organism | Homo sapiens |
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| Length | 649 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (12)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (78)
Diseases linked to this target (Open Targets).
- uridine-cytidineuria · score 0.49
- serum metabolite measurement · score 0.46
- BMI-adjusted waist-hip ratio · score 0.37
- BMI-adjusted waist circumference · score 0.36
- systolic blood pressure · score 0.34
- protein measurement · score 0.22
- cutaneous melanoma · score 0.12
- pathological myopia · score 0.11
- Myopia · score 0.11
- heel bone mineral density · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00337-F1 | alphafold | PREDICTED | 82.28 | — |
Amino-acid sequence (649 residues)
MENDPSRRRE SISLTPVAKG LENMGADFLE SLEEGQLPRS DLSPAEIRSS WSEAAPKPFS RWRNLQPALR ARSFCREHMQ LFRWIGTGLL CTGLSAFLLV ACLLDFQRAL ALFVLTCVVL TFLGHRLLKR LLGPKLRRFL KPQGHPRLLL WFKRGLALAA FLGLVLWLSL DTSQRPEQLV SFAGICVFVA LLFACSKHHC AVSWRAVSWG LGLQFVLGLL VIRTEPGFIA FEWLGEQIRI FLSYTKAGSS FVFGEALVKD VFAFQVLPII VFFSCVISVL YHVGLMQWVI LKIAWLMQVT MGTTATETLS VAGNIFVSQT EAPLLIRPYL ADMTLSEVHV VMTGGYATIA GSLLGAYISF GIDATSLIAA SVMAAPCALA LSKLVYPEVE ESKFRREEGV KLTYGDAQNL IEAASTGAAI SVKVVANIAA NLIAFLAVLD FINAALSWLG DMVDIQGLSF QLICSYILRP VAFLMGVAWE DCPVVAELLG IKLFLNEFVA YQDLSKYKQR RLAGAEEWVG DRKQWISVRA EVLTTFALCG FANFSSIGIM LGGLTSMVPQ RKSDFSQIVL RALFTGACVS LVNACMAGIL YMPRGAEVDC MSLLNTTLSS SSFEIYQCCR EAFQSVNPEF SPEALDNCCR FYNHTICAQ
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