About Muscarinic acetylcholine receptor M3
Muscarinic acetylcholine receptor M3 (CHRM3) is a protein
from Homo sapiens identified by UniProt accession
P20309, 590 residues long.
MolForge cross-references it against 0 known binders and
382 disease associations.
Target properties
| Protein name | Muscarinic acetylcholine receptor M3 |
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| UniProt accession | P20309 |
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| Gene | CHRM3 |
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| Organism | Homo sapiens |
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| Length | 590 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (382)
Diseases linked to this target (Open Targets).
- prune belly syndrome · score 0.69
- chronic obstructive pulmonary disease · score 0.67
- overactive bladder · score 0.61
- asthma · score 0.61
- urgency urinary incontinence · score 0.60
- Urinary incontinence · score 0.60
- chronic bronchitis · score 0.59
- Myopia · score 0.59
- emphysema · score 0.59
- cycloplegia · score 0.59
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P20309-F1 | alphafold | PREDICTED | 66.68 | — |
Amino-acid sequence (590 residues)
MTLHNNSTTS PLFPNISSSW IHSPSDAGLP PGTVTHFGSY NVSRAAGNFS SPDGTTDDPL GGHTVWQVVF IAFLTGILAL VTIIGNILVI VSFKVNKQLK TVNNYFLLSL ACADLIIGVI SMNLFTTYII MNRWALGNLA CDLWLAIDYV ASNASVMNLL VISFDRYFSI TRPLTYRAKR TTKRAGVMIG LAWVISFVLW APAILFWQYF VGKRTVPPGE CFIQFLSEPT ITFGTAIAAF YMPVTIMTIL YWRIYKETEK RTKELAGLQA SGTEAETENF VHPTGSSRSC SSYELQQQSM KRSNRRKYGR CHFWFTTKSW KPSSEQMDQD HSSSDSWNNN DAAASLENSA SSDEEDIGSE TRAIYSIVLK LPGHSTILNS TKLPSSDNLQ VPEEELGMVD LERKADKLQA QKSVDDGGSF PKSFSKLPIQ LESAVDTAKT SDVNSSVGKS TATLPLSFKE ATLAKRFALK TRSQITKRKR MSLVKEKKAA QTLSAILLAF IITWTPYNIM VLVNTFCDSC IPKTFWNLGY WLCYINSTVN PVCYALCNKT FRTTFKMLLL CQCDKKKRRK QQYQQRQSVI FHKRAPEQAL
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