Thiothixene

Typical Antipsychotic — NERVOUS SYSTEM

Key facts

Thiothixene is an ofp drug in the Typical Antipsychotic class catalogued in DrugCentral. It was first approved by the FDA in 1967. DrugCentral lists 27 molecular targets, including DRD3, DRD2 and HRH1. Recorded indications include Schizophrenia.

• Approval status: ofp (first approved 1967 by the FDA).
• Drug class: Typical Antipsychotic.
• Molecular targets: DRD3, DRD2, HRH1 and ADRA1A (27 listed in DrugCentral).
• Indications: Schizophrenia.
• ATC code: N05AF04 (Thioxanthene derivatives).
• Molecular formula: C23H29N3O2S2; molecular weight 443.64 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Schizophrenia

Contraindications (20)

• Agranulocytosis
• Alcohol withdrawal syndrome
• Angle-closure glaucoma
• Benign prostatic hyperplasia
• Breastfeeding (mother)
• Carcinoma of female breast
• Coma
• Disease of blood AND/OR blood-forming organ
• Disorder of cardiovascular system
• Drug Induced CNS Depression
• Epilepsy
• Leukopenia
• Neuroleptic malignant syndrome
• Neutropenic disorder
• Parkinsonism
• Retention of urine
• Senile dementia
• Shock
• Stupor
• Tardive dyskinesia

Mechanism & targets

• Established pharmacologic class: Typical Antipsychotic

Molecular targets (27)

Target	Gene	Action	Activity
D(3) dopamine receptor	DRD3	unknown	Ki 9.41
D(2) dopamine receptor	DRD2	antagonist	Ki 9.35
Histamine H1 receptor	HRH1	antagonist	Ki 8.40
Alpha-1A adrenergic receptor	ADRA1A	unknown	Ki 7.94
5-hydroxytryptamine receptor 7	HTR7	unknown	Ki 7.82
Alpha-1B adrenergic receptor	ADRA1B	unknown	Ki 7.46
Alpha-2B adrenergic receptor	ADRA2B	unknown	Ki 7.30
5-hydroxytryptamine receptor 2A	HTR2A	antagonist	Ki 7.30
D(1A) dopamine receptor	DRD1	unknown	Ki 7.29
Alpha-2C adrenergic receptor	ADRA2C	unknown	Ki 7.28
Alpha-2A adrenergic receptor	ADRA2A	unknown	Ki 7.10
5-hydroxytryptamine receptor 1B	HTR1B	unknown	Ki 6.82
D(4) dopamine receptor	DRD4	unknown	Ki 6.69
5-hydroxytryptamine receptor 6	HTR6	unknown	Ki 6.68
D(1B) dopamine receptor	DRD5	unknown	Ki 6.58
5-hydroxytryptamine receptor 5A	HTR5A	unknown	Ki 6.44
5-hydroxytryptamine receptor 1A	HTR1A	unknown	Ki 6.39
Histamine H2 receptor	HRH2	unknown	Ki 6.39
5-hydroxytryptamine receptor 1D	HTR1D	unknown	Ki 6.18
5-hydroxytryptamine receptor 2C	HTR2C	unknown	Ki 5.87

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1967-07-24	FDA	—	PFIZER

ATC classification

ATC code	Therapeutic hierarchy
N05AF04	NERVOUS SYSTEM › PSYCHOLEPTICS › ANTIPSYCHOTICS › Thioxanthene derivatives

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Parkinsonism	43.1
Tardive dyskinesia	40.6

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Thiothixene is on its molecule page.

• Molecular formula: C₂₃H₂₉N₃O₂S₂
• Molecular weight: 443.64 g/mol
• CAS number: —
• InChIKey: GFBKORZTTCHDGY-UWVJOHFNSA-N
• PubChem CID: 941651

CN(C)S(=O)(=O)C1=CC2=C(SC3=CC=CC=C3\C2=C\CCN2CCN(C)CC2)C=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Thiothixene used for?

DrugCentral lists the following indications for Thiothixene: Schizophrenia.

How does Thiothixene work?

Its molecular targets in DrugCentral include DRD3, DRD2 (antagonist), HRH1 (antagonist) and ADRA1A.

When was Thiothixene first approved?

Thiothixene was first approved by the FDA in 1967.

What drug class does Thiothixene belong to?

Thiothixene is in the Typical Antipsychotic class.

What is the chemical formula of Thiothixene?

Thiothixene has the molecular formula C23H29N3O2S2 and a molecular weight of 443.64 g/mol.

Sources

• DrugCentral drug card 2639 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1201 — compound record and bioactivity
• PubChem CID 941651 — chemical identifiers
• DrugBank DB01623 — drug record
• FDA UNII 7318FJ13YJ — substance identity
• DailyMed: FDA labels for Thiothixene — current prescribing information (label search)
• UniProt P35462 (DRD3) — target protein
• UniProt P14416 (DRD2) — target protein
• UniProt P35367 (HRH1) — target protein
• UniProt P35348 (ADRA1A) — target protein
• UniProt P34969 (HTR7) — target protein
• UniProt P35368 (ADRA1B) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.