D(1B) dopamine receptor (DRD5)

About D(1B) dopamine receptor

D(1B) dopamine receptor (DRD5) is a protein from Homo sapiens identified by UniProt accession P21918, 477 residues long. MolForge cross-references it against 0 known binders and 214 disease associations.

Target properties

Protein name	D(1B) dopamine receptor
UniProt accession	P21918
Gene	DRD5
Organism	Homo sapiens
Length	477 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (214)

Diseases linked to this target (Open Targets).

schizophrenia · score 0.53
cardiovascular disease · score 0.53
unipolar depression · score 0.50
Parkinson disease · score 0.50
Tourette syndrome · score 0.39
psychosis · score 0.37
Tics · score 0.37
schizoaffective disorder · score 0.37
Benign essential blepharospasm · score 0.37
urate measurement · score 0.29

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P21918-F1	alphafold	PREDICTED	69.13	—

Amino-acid sequence (477 residues)

MLPPGSNGTA YPGQFALYQQ LAQGNAVGGS AGAPPLGPSQ VVTACLLTLL IIWTLLGNVL VCAAIVRSRH LRANMTNVFI VSLAVSDLFV ALLVMPWKAV AEVAGYWPFG AFCDVWVAFD IMCSTASILN LCVISVDRYW AISRPFRYKR KMTQRMALVM VGLAWTLSIL ISFIPVQLNW HRDQAASWGG LDLPNNLANW TPWEEDFWEP DVNAENCDSS LNRTYAISSS LISFYIPVAI MIVTYTRIYR IAQVQIRRIS SLERAAEHAQ SCRSSAACAP DTSLRASIKK ETKVLKTLSV IMGVFVCCWL PFFILNCMVP FCSGHPEGPP AGFPCVSETT FDVFVWFGWA NSSLNPVIYA FNADFQKVFA QLLGCSHFCS RTPVETVNIS NELISYNQDI VFHKEIAAAY IHMMPNAVTP GNREVDNDEE EGPFDRMFQI YQTSPDGDPV AESVWELDCE GEISLDKITP FTPNGFH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards