Talipexole

Drug profile

Key facts

Talipexole is a drug catalogued in DrugCentral. DrugCentral lists 12 molecular targets, including Drd2, Adra2b|Adra2c|Adra2a and DRD3. Recorded indications include Parkinson's disease.

• Molecular targets: Drd2, Adra2b|Adra2c|Adra2a, DRD3 and ADRA2A (12 listed in DrugCentral).
• Indications: Parkinson's disease.
• Molecular formula: C10H15N3S; molecular weight 209.32 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Parkinson's disease

Mechanism & targets

Molecular targets (12)

Target	Gene	Action	Activity
D(2) dopamine receptor	Drd2	unknown	Ki 8.24
Adrenergic receptor alpha-2	Adra2b|Adra2c|Adra2a	unknown	IC50 7.60
D(3) dopamine receptor	DRD3	unknown	Ki 7.48
Alpha-2A adrenergic receptor	ADRA2A	unknown	Ki 6.92
Alpha-2C adrenergic receptor	ADRA2C	unknown	Ki 6.70
Alpha-2B adrenergic receptor	ADRA2B	unknown	Ki 6.69
D(4) dopamine receptor	DRD4	unknown	Ki 6.48
D(2) dopamine receptor	DRD2	unknown	Ki 6.31
Alpha-1D adrenergic receptor	ADRA1D	unknown	Ki 5.90
5-hydroxytryptamine receptor 1A	HTR1A	unknown	Ki 5.77
D(1B) dopamine receptor	DRD5	unknown	Ki 5.46
Alpha-1B adrenergic receptor	ADRA1B	unknown	Ki 5.41

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
—	PMDA	—	—

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Talipexole is on its molecule page.

• Molecular formula: C₁₀H₁₅N₃S
• Molecular weight: 209.32 g/mol
• CAS number: —
• InChIKey: DHSSDEDRBUKTQY-UHFFFAOYSA-N
• PubChem CID: 5374

NC1=NC2=C(CCN(CC=C)CC2)S1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Talipexole used for?

DrugCentral lists the following indications for Talipexole: Parkinson's disease.

How does Talipexole work?

Its molecular targets in DrugCentral include Drd2, Adra2b|Adra2c|Adra2a, DRD3 and ADRA2A.

What is the chemical formula of Talipexole?

Talipexole has the molecular formula C10H15N3S and a molecular weight of 209.32 g/mol.

Sources

• DrugCentral drug card 2558 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1504869 — compound record and bioactivity
• PubChem CID 5374 — chemical identifiers
• FDA UNII 7AM2J46Z1Y — substance identity
• UniProt P35462 (DRD3) — target protein
• UniProt P08913 (ADRA2A) — target protein
• UniProt P18825 (ADRA2C) — target protein
• UniProt P18089 (ADRA2B) — target protein
• UniProt P21917 (DRD4) — target protein
• UniProt P14416 (DRD2) — target protein

How this page is built: methodology · editorial policy & corrections.