Alpha-2B adrenergic receptor (ADRA2B)

About Alpha-2B adrenergic receptor

Alpha-2B adrenergic receptor (ADRA2B) is a protein from Homo sapiens identified by UniProt accession P18089, 450 residues long. MolForge cross-references it against 0 known binders and 380 disease associations.

Target properties

Protein name	Alpha-2B adrenergic receptor
UniProt accession	P18089
Gene	ADRA2B
Organism	Homo sapiens
Length	450 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (380)

Diseases linked to this target (Open Targets).

Parkinson disease · score 0.64
pain · score 0.61
unipolar depression · score 0.60
attention deficit hyperactivity disorder · score 0.60
Nasal congestion · score 0.60
hypotension · score 0.60
seasonal allergic rhinitis · score 0.60
hypertension · score 0.60
delirium · score 0.60
asthma · score 0.60

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P18089-F1	alphafold	PREDICTED	71.55	—

Amino-acid sequence (450 residues)

MDHQDPYSVQ ATAAIAAAIT FLILFTIFGN ALVILAVLTS RSLRAPQNLF LVSLAAADIL VATLIIPFSL ANELLGYWYF RRTWCEVYLA LDVLFCTSSI VHLCAISLDR YWAVSRALEY NSKRTPRRIK CIILTVWLIA AVISLPPLIY KGDQGPQPRG RPQCKLNQEA WYILASSIGS FFAPCLIMIL VYLRIYLIAK RSNRRGPRAK GGPGQGESKQ PRPDHGGALA SAKLPALASV ASAREVNGHS KSTGEKEEGE TPEDTGTRAL PPSWAALPNS GQGQKEGVCG ASPEDEAEEE EEEEEEEEEC EPQAVPVSPA SACSPPLQQP QGSRVLATLR GQVLLGRGVG AIGGQWWRRR AQLTREKRFT FVLAVVIGVF VLCWFPFFFS YSLGAICPKH CKVPHGLFQF FFWIGYCNSS LNPVIYTIFN QDFRRAFRRI LCRPWTQTAW

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards