Econazole

Azole Antifungal — DERMATOLOGICALS

Key facts

Econazole is an ofp drug in the Azole Antifungal class catalogued in DrugCentral. It was first approved by the FDA in 1982. DrugCentral lists 68 molecular targets, including TBXAS1, CYP2C19 and CYP3A4. Recorded indications include Candidiasis of skin, Pityriasis versicolor, Tinea corporis and Tinea cruris.

• Approval status: ofp (first approved 1982 by the FDA).
• Drug class: Azole Antifungal.
• Molecular targets: TBXAS1, CYP2C19, CYP3A4 and CYP51A1 (68 listed in DrugCentral).
• Indications: Candidiasis of skin, Pityriasis versicolor, Tinea corporis, Tinea cruris and Tinea pedis.
• ATC code: D01AC03 (Imidazole and triazole derivatives).
• Molecular formula: C18H15Cl3N2O; molecular weight 381.68 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (5)

• Candidiasis of skin
• Pityriasis versicolor
• Tinea corporis
• Tinea cruris
• Tinea pedis

Off-label uses (1)

• Paronychia

Mechanism & targets

• Established pharmacologic class: Azole Antifungal

Molecular targets (68)

Target	Gene	Action	Activity
Thromboxane-A synthase	TBXAS1	unknown	IC50 7.54
Cytochrome P450 2C19	CYP2C19	unknown	IC50 7.40
Cytochrome P450 3A4	CYP3A4	unknown	IC50 7.30
Lanosterol 14-alpha demethylase	CYP51A1	unknown	IC50 7.30
Mycocyclosin synthase	cyp121	unknown	Kd 7.14
Lanosterol 14-alpha demethylase	cyp51	unknown	Kd 6.70
Cytochrome P450 2C9	CYP2C9	unknown	IC50 6.70
Sodium-dependent serotonin transporter	SLC6A4	unknown	Ki 6.65
Muscarinic acetylcholine receptor M4	CHRM4	unknown	Ki 6.53
Cytochrome P450 1A2	CYP1A2	unknown	IC50 6.52
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase	CYP8B1	unknown	IC50 6.51
Steroid 17-alpha-hydroxylase/17,20 lyase	CYP17A1	unknown	Ki 6.49
Muscarinic acetylcholine receptor M3	CHRM3	unknown	Ki 6.42
Cytochrome P450 2D6	CYP2D6	unknown	IC50 6.40
Transient receptor potential cation channel subfamily M member 8	TRPM8	unknown	IC50 6.38
Delta-type opioid receptor	OPRD1	unknown	Ki 6.29
Muscarinic acetylcholine receptor M1	CHRM1	unknown	Ki 6.20
Sodium-dependent dopamine transporter	SLC6A3	unknown	Ki 6.18
5-hydroxytryptamine receptor 2A	HTR2A	unknown	Ki 5.94
Muscarinic acetylcholine receptor M2	CHRM2	unknown	Ki 5.94

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1982-12-23	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
D01AC03	DERMATOLOGICALS › ANTIFUNGALS FOR DERMATOLOGICAL USE › ANTIFUNGALS FOR TOPICAL USE › Imidazole and triazole derivatives
G01AF05	GENITO URINARY SYSTEM AND SEX HORMONES › GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS › ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS › Imidazole derivatives
G01AF55	GENITO URINARY SYSTEM AND SEX HORMONES › GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS › ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS › Imidazole derivatives

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Acute generalised exanthematous pustulosis	158.9
Rash maculo-papular	135.5
Acute motor-sensory axonal neuropathy	97.3
Angiodermatitis	84.3
International normalised ratio increased	79.4
Eosinophilia	76.7
Drug reaction with eosinophilia and systemic symptoms	69.8
Purpura	55.2
Granulomatous liver disease	45.9
Purpura senile	45.0
Tarsal tunnel syndrome	45.0
Dermatitis exfoliative generalised	43.2

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Econazole is on its molecule page.

• Molecular formula: C₁₈H₁₅Cl₃N₂O
• Molecular weight: 381.68 g/mol
• CAS number: 27220-47-9
• InChIKey: LEZWWPYKPKIXLL-UHFFFAOYSA-N
• PubChem CID: 3198

ClC1=CC=C(COC(CN2C=CN=C2)C2=C(Cl)C=C(Cl)C=C2)C=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Econazole used for?

DrugCentral lists the following indications for Econazole: Candidiasis of skin, Pityriasis versicolor, Tinea corporis, Tinea cruris and Tinea pedis.

How does Econazole work?

Its molecular targets in DrugCentral include TBXAS1, CYP2C19, CYP3A4 and CYP51A1.

When was Econazole first approved?

Econazole was first approved by the FDA in 1982.

What drug class does Econazole belong to?

Econazole is in the Azole Antifungal class.

What is the chemical formula of Econazole?

Econazole has the molecular formula C18H15Cl3N2O and a molecular weight of 381.68 g/mol.

Sources

• DrugCentral drug card 983 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1201049 — compound record and bioactivity
• PubChem CID 3198 — chemical identifiers
• DrugBank DB01127 — drug record
• FDA UNII 6Z1Y2V4A7M — substance identity
• DailyMed: FDA labels for Econazole — current prescribing information (label search)
• UniProt P24557 (TBXAS1) — target protein
• UniProt P33261 (CYP2C19) — target protein
• UniProt P08684 (CYP3A4) — target protein
• UniProt Q16850 (CYP51A1) — target protein
• UniProt P11712 (CYP2C9) — target protein
• UniProt P31645 (SLC6A4) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.