Muscarinic acetylcholine receptor M2 (CHRM2)

About Muscarinic acetylcholine receptor M2

Muscarinic acetylcholine receptor M2 (CHRM2) is a protein from Homo sapiens identified by UniProt accession P08172, 466 residues long. MolForge cross-references it against 0 known binders and 242 disease associations.

Target properties

Protein name	Muscarinic acetylcholine receptor M2
UniProt accession	P08172
Gene	CHRM2
Organism	Homo sapiens
Length	466 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (242)

Diseases linked to this target (Open Targets).

overactive bladder · score 0.61
chronic obstructive pulmonary disease · score 0.60
urgency urinary incontinence · score 0.60
Urinary incontinence · score 0.60
Myopia · score 0.59
Mydriasis · score 0.57
cycloplegia · score 0.57
Hyperhidrosis · score 0.57
seasonal allergic rhinitis · score 0.57
Parkinson disease · score 0.57

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P08172-F1	alphafold	PREDICTED	72.05	—

Amino-acid sequence (466 residues)

MNNSTNSSNN SLALTSPYKT FEVVFIVLVA GSLSLVTIIG NILVMVSIKV NRHLQTVNNY FLFSLACADL IIGVFSMNLY TLYTVIGYWP LGPVVCDLWL ALDYVVSNAS VMNLLIISFD RYFCVTKPLT YPVKRTTKMA GMMIAAAWVL SFILWAPAIL FWQFIVGVRT VEDGECYIQF FSNAAVTFGT AIAAFYLPVI IMTVLYWHIS RASKSRIKKD KKEPVANQDP VSPSLVQGRI VKPNNNNMPS SDDGLEHNKI QNGKAPRDPV TENCVQGEEK ESSNDSTSVS AVASNMRDDE ITQDENTVST SLGHSKDENS KQTCIRIGTK TPKSDSCTPT NTTVEVVGSS GQNGDEKQNI VARKIVKMTK QPAKKKPPPS REKKVTRTIL AILLAFIITW APYNVMVLIN TFCAPCIPNT VWTIGYWLCY INSTINPACY ALCNATFKKT FKHLLMCHYK NIGATR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards