Strychnine
Drug profile
Also known as: (-)-Strychnine, Strychnidin-10-one, strychnin, strychnine HCl, strychnine hydrochloride, strychnine sulfate
Data last refreshed: (DrugCentral release 2024-11-01)
Key facts
Strychnine is a drug catalogued in DrugCentral. DrugCentral lists 9 molecular targets, including Glra1, TAS2R46 and CHRM3.
- Molecular targets: Glra1, TAS2R46, CHRM3 and TAS2R10 (9 listed in DrugCentral).
- Molecular formula: C21H22N2O2; molecular weight 334.42 g/mol.
Mechanism & targets
Molecular targets (9)
| Target | Gene | Action | Activity |
|---|---|---|---|
| Glycine receptor subunit alpha-1 | Glra1 | unknown | Ki 7.92 |
| Taste receptor type 2 member 46 | TAS2R46 | agonist | EC50 6.37 |
| Muscarinic acetylcholine receptor M3 | CHRM3 | allosteric modulator | Kd 5.70 |
| Taste receptor type 2 member 10 | TAS2R10 | unknown | EC50 5.30 |
| Muscarinic acetylcholine receptor M4 | CHRM4 | allosteric modulator | Kd 5.00 |
| Muscarinic acetylcholine receptor M1 | CHRM1 | allosteric modulator | Kd 5.00 |
| Muscarinic acetylcholine receptor M2 | CHRM2 | allosteric modulator | Kd 5.00 |
| Glycine receptor subunit alpha-1 | GLRA1 | unknown | IC50 4.70 |
| Sodium channel alpha subunits; brain (Types I, II, III) | SCN1A|SCN2A|SCN3A | unknown | IC50 4.68 |
Chemical structure
| Molecular formula | C21H22N2O2 |
|---|---|
| Molecular weight | 334.42 g/mol |
| CAS number | 57-24-9 |
| InChIKey | QMGVPVSNSZLJIA-FVWCLLPLSA-N |
| PubChem CID | 441071 |
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
How does Strychnine work?
Its molecular targets in DrugCentral include Glra1, TAS2R46 (agonist), CHRM3 (allosteric modulator) and TAS2R10.
What is the chemical formula of Strychnine?
Strychnine has the molecular formula C21H22N2O2 and a molecular weight of 334.42 g/mol.
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Sources
- DrugCentral drug card 2484 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
- ChEMBL CHEMBL2103753 — compound record and bioactivity
- PubChem CID 441071 — chemical identifiers
- DrugBank DB15954 — drug record
- FDA UNII H9Y79VD43J — substance identity
- UniProt P59540 (TAS2R46) — target protein
- UniProt P20309 (CHRM3) — target protein
- UniProt Q9NYW0 (TAS2R10) — target protein
- UniProt P08173 (CHRM4) — target protein
- UniProt P11229 (CHRM1) — target protein
- UniProt P08172 (CHRM2) — target protein
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