Glycine receptor subunit alpha-1 (GLRA1)

About Glycine receptor subunit alpha-1

Glycine receptor subunit alpha-1 (GLRA1) is a protein from Homo sapiens identified by UniProt accession P23415, 457 residues long. MolForge cross-references it against 0 known binders and 393 disease associations.

Target properties

Protein name	Glycine receptor subunit alpha-1
UniProt accession	P23415
Gene	GLRA1
Organism	Homo sapiens
Length	457 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (393)

Diseases linked to this target (Open Targets).

hereditary hyperekplexia · score 0.74
pain · score 0.58
delirium · score 0.56
Agitation · score 0.55
coronary artery disease · score 0.55
ischemia reperfusion injury · score 0.54
kidney failure · score 0.53
acute respiratory distress syndrome · score 0.52
post operative nausea and vomiting · score 0.50
hypotension · score 0.50

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P23415-F1	alphafold	PREDICTED	83.99	—

Amino-acid sequence (457 residues)

MYSFNTLRLY LWETIVFFSL AASKEAEAAR SAPKPMSPSD FLDKLMGRTS GYDARIRPNF KGPPVNVSCN IFINSFGSIA ETTMDYRVNI FLRQQWNDPR LAYNEYPDDS LDLDPSMLDS IWKPDLFFAN EKGAHFHEIT TDNKLLRISR NGNVLYSIRI TLTLACPMDL KNFPMDVQTC IMQLESFGYT MNDLIFEWQE QGAVQVADGL TLPQFILKEE KDLRYCTKHY NTGKFTCIEA RFHLERQMGY YLIQMYIPSL LIVILSWISF WINMDAAPAR VGLGITTVLT MTTQSSGSRA SLPKVSYVKA IDIWMAVCLL FVFSALLEYA AVNFVSRQHK ELLRFRRKRR HHKSPMLNLF QEDEAGEGRF NFSAYGMGPA CLQAKDGISV KGANNSNTTN PPPAPSKSPE EMRKLFIQRA KKIDKISRIG FPMAFLIFNM FYWIIYKIVR REDVHNQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards