Dronabinol

Cannabinoid — ALIMENTARY TRACT AND METABOLISM

Key facts

Dronabinol is an ofp drug in the Cannabinoid class catalogued in DrugCentral. It was first approved by the FDA in 1985. DrugCentral lists 21 molecular targets, including CNR1, CNR2 and Cnr2. Recorded indications include Anorexia from HIV and Chemotherapy-induced nausea and vomiting.

• Approval status: ofp (first approved 1985 by the FDA).
• Drug class: Cannabinoid.
• Molecular targets: CNR1, CNR2, Cnr2 and DRD3 (21 listed in DrugCentral).
• Indications: Anorexia from HIV and Chemotherapy-induced nausea and vomiting.
• ATC code: A04AD10 (Other antiemetics).
• Molecular formula: C21H30O2; molecular weight 314.47 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (2)

• Anorexia from HIV
• Chemotherapy-induced nausea and vomiting

Contraindications (12)

• Alcoholism
• Bipolar disorder
• Breastfeeding (mother)
• Depressive disorder
• Epilepsy
• Hypertensive disorder
• Low blood pressure
• Lowered convulsive threshold
• Schizophrenia
• Substance abuse
• Syncope
• Tachyarrhythmia

Mechanism & targets

• Established pharmacologic class: Cannabinoid

Molecular targets (21)

Target	Gene	Action	Activity
Cannabinoid receptor 1	CNR1	agonist	Ki 8.54
Cannabinoid receptor 2	CNR2	unknown	Ki 8.48
Cannabinoid receptor 2	Cnr2	unknown	Ki 8.04
D(3) dopamine receptor	DRD3	unknown	EC50 7.99
Cannabinoid receptor 1	Cnr1	unknown	Ki 7.43
Cannabinoid receptor 1	Cnr1	unknown	Ki 7.40
Cannabinoid receptor	CNR1|CNR2	unknown	Ki 7.39
Cannabinoid receptor	Cnr1|Cnr2	unknown	Ki 7.34
Transient receptor potential cation channel subfamily M member 8	TRPM8	unknown	IC50 6.80
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	ENPP2	unknown	EC50 6.34
N-arachidonyl glycine receptor	GPR18	unknown	EC50 6.02
Glycine receptor subunit alpha-2	GLRA2	allosteric modulator	EC50 6.00
Glycine receptor subunit alpha-1	GLRA1	unknown	EC50 5.89
Glycine receptor subunit alpha-3	GLRA3	allosteric modulator	EC50 5.30
Monoacylglycerol lipase ABHD12	ABHD12	unknown	IC50 4.94
Transient receptor potential cation channel subfamily A member 1	TRPA1	activator	EC50 4.90
G-protein coupled receptor 55	GPR55	unknown	IC50 4.85
L-lactate dehydrogenase A chain	LDHA	unknown	Ki 4.85
Transient receptor potential cation channel subfamily V member 2	Trpv2	activator	EC50 4.85
Fatty-acid amide hydrolase 1	FAAH	unknown	IC50 4.36

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1985-05-31	FDA	—	ABBVIE	Yes

ATC classification

ATC code	Therapeutic hierarchy
A04AD10	ALIMENTARY TRACT AND METABOLISM › ANTIEMETICS AND ANTINAUSEANTS › ANTIEMETICS AND ANTINAUSEANTS › Other antiemetics

Pharmacogenomics

Drug-label and guideline annotations from PharmGKB and CPIC.

• FDA label: CYP2C9 · Actionable PGx
• HCSC label

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Drug abuse	425.5
Toxicity to various agents	315.1
Drug screen positive	250.6
Poisoning	187.4
Product temperature excursion issue	162.2
Brain oedema	160.4
Substance abuse	120.5
Asphyxia	115.5
Vascular device infection	104.6
Failure to thrive	101.2
Nausea	100.7
Dehydration	99.6

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Dronabinol is on its molecule page.

• Molecular formula: C₂₁H₃₀O₂
• Molecular weight: 314.47 g/mol
• CAS number: 1972-08-3
• InChIKey: CYQFCXCEBYINGO-IAGOWNOFSA-N
• PubChem CID: 16078

CCCCCC1=CC(O)=C2[C@@H]3C=C(C)CC[C@H]3C(C)(C)OC2=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Dronabinol used for?

DrugCentral lists the following indications for Dronabinol: Anorexia from HIV and Chemotherapy-induced nausea and vomiting.

How does Dronabinol work?

Its molecular targets in DrugCentral include CNR1 (agonist), CNR2, Cnr2 and DRD3.

When was Dronabinol first approved?

Dronabinol was first approved by the FDA in 1985.

What drug class does Dronabinol belong to?

Dronabinol is in the Cannabinoid class.

What is the chemical formula of Dronabinol?

Dronabinol has the molecular formula C21H30O2 and a molecular weight of 314.47 g/mol.

Sources

• DrugCentral drug card 4109 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL465 — compound record and bioactivity
• PubChem CID 16078 — chemical identifiers
• DrugBank DB00470 — drug record
• FDA UNII 7J8897W37S — substance identity
• DailyMed: FDA labels for Dronabinol — current prescribing information (label search)
• UniProt P21554 (CNR1) — target protein
• UniProt P34972 (CNR2) — target protein
• UniProt P35462 (DRD3) — target protein
• UniProt Q7Z2W7 (TRPM8) — target protein
• UniProt Q13822 (ENPP2) — target protein
• UniProt Q14330 (GPR18) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral
• PharmGKB / CPIC — pharmacogenomic label annotations

How this page is built: methodology · editorial policy & corrections.