About Glycine receptor subunit alpha-2
Glycine receptor subunit alpha-2 (GLRA2) is a protein
from Homo sapiens identified by UniProt accession
P23416, 452 residues long.
MolForge cross-references it against 0 known binders and
96 disease associations.
Target properties
| Protein name | Glycine receptor subunit alpha-2 |
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| UniProt accession | P23416 |
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| Gene | GLRA2 |
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| Organism | Homo sapiens |
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| Length | 452 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (7)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (96)
Diseases linked to this target (Open Targets).
- intellectual developmental disorder, X-linked, syndromic, Pilorge type · score 0.76
- neurodegenerative disease · score 0.34
- cutaneous melanoma · score 0.18
- glioblastoma multiforme · score 0.18
- genetic disorder · score 0.17
- neuroinflammatory disorder · score 0.14
- lung adenocarcinoma · score 0.12
- squamous cell lung carcinoma · score 0.12
- breast adenocarcinoma · score 0.10
- Blackfan-Diamond anemia · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P23416-F1 | alphafold | PREDICTED | 83.79 | — |
Amino-acid sequence (452 residues)
MNRQLVNILT ALFAFFLETN HFRTAFCKDH DSRSGKQPSQ TLSPSDFLDK LMGRTSGYDA RIRPNFKGPP VNVTCNIFIN SFGSVTETTM DYRVNIFLRQ QWNDSRLAYS EYPDDSLDLD PSMLDSIWKP DLFFANEKGA NFHDVTTDNK LLRISKNGKV LYSIRLTLTL SCPMDLKNFP MDVQTCTMQL ESFGYTMNDL IFEWLSDGPV QVAEGLTLPQ FILKEEKELG YCTKHYNTGK FTCIEVKFHL ERQMGYYLIQ MYIPSLLIVI LSWVSFWINM DAAPARVALG ITTVLTMTTQ SSGSRASLPK VSYVKAIDIW MAVCLLFVFA ALLEYAAVNF VSRQHKEFLR LRRRQKRQNK EEDVTRESRF NFSGYGMGHC LQVKDGTAVK ATPANPLPQP PKDGDAIKKK FVDRAKRIDT ISRAAFPLAF LIFNIFYWIT YKIIRHEDVH KK
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