L-lactate dehydrogenase A chain (LDHA)

About L-lactate dehydrogenase A chain

L-lactate dehydrogenase A chain (LDHA) is a protein from Homo sapiens identified by UniProt accession P00338, 332 residues long. MolForge cross-references it against 0 known binders and 769 disease associations.

Target properties

Protein name	L-lactate dehydrogenase A chain
UniProt accession	P00338
Gene	LDHA
Organism	Homo sapiens
Length	332 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (5)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (769)

Diseases linked to this target (Open Targets).

glycogen storage disease due to lactate dehydrogenase M-subunit deficiency · score 0.75
disorder of glycogen metabolism · score 0.50
primary hyperoxaluria · score 0.38
serum amyloid A protein measurement · score 0.31
body height · score 0.28
genetic disorder · score 0.18
neoplasm · score 0.12
hepatocellular carcinoma · score 0.11
cancer · score 0.11
breast cancer · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P00338-F1	alphafold	PREDICTED	96.19	—

Amino-acid sequence (332 residues)

MATLKDQLIY NLLKEEQTPQ NKITVVGVGA VGMACAISIL MKDLADELAL VDVIEDKLKG EMMDLQHGSL FLRTPKIVSG KDYNVTANSK LVIITAGARQ QEGESRLNLV QRNVNIFKFI IPNVVKYSPN CKLLIVSNPV DILTYVAWKI SGFPKNRVIG SGCNLDSARF RYLMGERLGV HPLSCHGWVL GEHGDSSVPV WSGMNVAGVS LKTLHPDLGT DKDKEQWKEV HKQVVESAYE VIKLKGYTSW AIGLSVADLA ESIMKNLRRV HPVSTMIKGL YGIKDDVFLS VPCILGQNGI SDLVKVTLTS EEEARLKKSA DTLWGIQKEL QF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards