Gossypol

Drug profile

Key facts

Gossypol is a drug catalogued in DrugCentral. DrugCentral lists 21 molecular targets, including BCL2, MCL1 and ASPH.

• Molecular targets: BCL2, MCL1, ASPH and BAD (21 listed in DrugCentral).
• Molecular formula: C30H30O8; molecular weight 518.56 g/mol.

Mechanism & targets

Molecular targets (21)

Target	Gene	Action	Activity
Apoptosis regulator Bcl-2	BCL2	unknown	Ki 6.77
Induced myeloid leukemia cell differentiation protein Mcl-1	MCL1	unknown	Ki 6.74
Aspartyl/asparaginyl beta-hydroxylase	ASPH	unknown	IC50 6.60
Bcl2-associated agonist of cell death	BAD	unknown	Ki 6.34
Bcl-2-like protein 1	BCL2L1	unknown	Ki 6.32
Aldose reductase	AKR1B1	unknown	Ki 6.30
Inosine-5'-monophosphate dehydrogenase	guaB	unknown	IC50 6.05
L-lactate dehydrogenase B chain	LDHB	unknown	Ki 5.85
L-lactate dehydrogenase A chain	LDHA	unknown	Ki 5.72
Malate dehydrogenase	—	unknown	IC50 5.69
Estrogen receptor	ESR1	unknown	IC50 5.59
Lactate dehydrogenase	LDH	unknown	IC50 5.58
Malate dehydrogenase, mitochondrial	MDH2	unknown	IC50 5.55
DNA-3-methyladenine glycosylase	MPG	unknown	IC50 5.52
Malate dehydrogenase, cytoplasmic	MDH1	unknown	IC50 5.24
Androgen receptor	AR	unknown	IC50 5.14
Kinesin-like protein 1	KIF11	unknown	IC50 4.97
Replicase polyprotein 1ab	REP	unknown	IC50 4.85
Apoptosis regulator Bcl-W	BCL2L2	unknown	Ki 4.75
Solute carrier family 2, facilitated glucose transporter member 1	SLC2A1	unknown	Ki 4.70

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Gossypol is on its molecule page.

• Molecular formula: C₃₀H₃₀O₈
• Molecular weight: 518.56 g/mol
• CAS number: 303-45-7
• InChIKey: QBKSWRVVCFFDOT-UHFFFAOYSA-N
• PubChem CID: 3503

CC(C)C1=C(O)C(O)=C(C=O)C2=C(O)C(=C(C)C=C12)C1=C(O)C2=C(C=O)C(O)=C(O)C(C(C)C)=C2C=C1C

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Gossypol work?

Its molecular targets in DrugCentral include BCL2, MCL1, ASPH and BAD.

What is the chemical formula of Gossypol?

Gossypol has the molecular formula C30H30O8 and a molecular weight of 518.56 g/mol.

Sources

• DrugCentral drug card 1328 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL51483 — compound record and bioactivity
• PubChem CID 3503 — chemical identifiers
• DrugBank DB13044 — drug record
• FDA UNII KAV15B369O — substance identity
• UniProt P10415 (BCL2) — target protein
• UniProt Q07820 (MCL1) — target protein
• UniProt Q12797 (ASPH) — target protein
• UniProt Q92934 (BAD) — target protein
• UniProt Q07817 (BCL2L1) — target protein
• UniProt P15121 (AKR1B1) — target protein

How this page is built: methodology · editorial policy & corrections.