About Aldo-keto reductase family 1 member B1
Aldo-keto reductase family 1 member B1 (AKR1B1) is a protein
from Homo sapiens identified by UniProt accession
P15121, 316 residues long.
MolForge cross-references it against 0 known binders and
405 disease associations.
Target properties
| Protein name | Aldo-keto reductase family 1 member B1 |
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| UniProt accession | P15121 |
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| Gene | AKR1B1 |
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| Organism | Homo sapiens |
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| Length | 316 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (405)
Diseases linked to this target (Open Targets).
- diabetes mellitus · score 0.47
- neurodegenerative disease · score 0.37
- diabetic retinopathy · score 0.27
- PMM2-congenital disorder of glycosylation · score 0.26
- ovarian cancer · score 0.18
- squamous cell lung carcinoma · score 0.16
- hypertension · score 0.15
- systolic blood pressure · score 0.13
- white matter growth measurement · score 0.13
- blood pressure · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P15121-F1 | alphafold | PREDICTED | 98.33 | — |
Amino-acid sequence (316 residues)
MASRLLLNNG AKMPILGLGT WKSPPGQVTE AVKVAIDVGY RHIDCAHVYQ NENEVGVAIQ EKLREQVVKR EELFIVSKLW CTYHEKGLVK GACQKTLSDL KLDYLDLYLI HWPTGFKPGK EFFPLDESGN VVPSDTNILD TWAAMEELVD EGLVKAIGIS NFNHLQVEMI LNKPGLKYKP AVNQIECHPY LTQEKLIQYC QSKGIVVTAY SPLGSPDRPW AKPEDPSLLE DPRIKAIAAK HNKTTAQVLI RFPMQRNLVV IPKSVTPERI AENFKVFDFE LSSQDMTTLL SYNRNWRVCA LLSCTSHKDY PFHEEF
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