Apoptosis regulator Bcl-2 (BCL2)

About Apoptosis regulator Bcl-2

Apoptosis regulator Bcl-2 (BCL2) is a protein from Homo sapiens identified by UniProt accession P10415, 239 residues long. MolForge cross-references it against 0 known binders and 1,942 disease associations.

Target properties

Protein name	Apoptosis regulator Bcl-2
UniProt accession	P10415
Gene	BCL2
Organism	Homo sapiens
Length	239 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (4)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (1942)

Diseases linked to this target (Open Targets).

chronic lymphocytic leukemia · score 0.72
neurodegenerative disease · score 0.54
type 2 diabetes mellitus · score 0.54
lymphocyte count · score 0.53
body mass index · score 0.52
eosinophil count · score 0.52
sex hormone-binding globulin measurement · score 0.52
mean corpuscular volume · score 0.52
reticulocyte count · score 0.51
monocyte count · score 0.51

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P10415-F1	alphafold	PREDICTED	72.02	—

Amino-acid sequence (239 residues)

MAHAGRTGYD NREIVMKYIH YKLSQRGYEW DAGDVGAAPP GAAPAPGIFS SQPGHTPHPA ASRDPVARTS PLQTPAAPGA AAGPALSPVP PVVHLTLRQA GDDFSRRYRR DFAEMSSQLH LTPFTARGRF ATVVEELFRD GVNWGRIVAF FEFGGVMCVE SVNREMSPLV DNIALWMTEY LNRHLHTWIQ DNGGWDAFVE LYGPSMRPLF DFSWLSLKTL LSLALVGACI TLGAYLGHK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards