About Solute carrier family 2, facilitated glucose transporter member 1
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1) is a protein
from Homo sapiens identified by UniProt accession
P11166, 492 residues long.
MolForge cross-references it against 0 known binders and
1,059 disease associations.
Target properties
| Protein name | Solute carrier family 2, facilitated glucose transporter member 1 |
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| UniProt accession | P11166 |
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| Gene | SLC2A1 |
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| Organism | Homo sapiens |
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| Length | 492 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (1059)
Diseases linked to this target (Open Targets).
- encephalopathy due to GLUT1 deficiency · score 0.86
- childhood onset GLUT1 deficiency syndrome 2 · score 0.82
- generalised epilepsy · score 0.80
- dystonia 9 · score 0.79
- Paroxysmal exertion-induced dyskinesia · score 0.79
- hereditary cryohydrocytosis with reduced stomatin · score 0.76
- Paroxysmal dystonic choreathetosis with episodic ataxia and spasticity · score 0.64
- Intellectual disability · score 0.62
- Seizure · score 0.60
- GLUT1 deficiency syndrome · score 0.60
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P11166-F1 | alphafold | PREDICTED | 90.26 | — |
Amino-acid sequence (492 residues)
MEPSSKKLTG RLMLAVGGAV LGSLQFGYNT GVINAPQKVI EEFYNQTWVH RYGESILPTT LTTLWSLSVA IFSVGGMIGS FSVGLFVNRF GRRNSMLMMN LLAFVSAVLM GFSKLGKSFE MLILGRFIIG VYCGLTTGFV PMYVGEVSPT ALRGALGTLH QLGIVVGILI AQVFGLDSIM GNKDLWPLLL SIIFIPALLQ CIVLPFCPES PRFLLINRNE ENRAKSVLKK LRGTADVTHD LQEMKEESRQ MMREKKVTIL ELFRSPAYRQ PILIAVVLQL SQQLSGINAV FYYSTSIFEK AGVQQPVYAT IGSGIVNTAF TVVSLFVVER AGRRTLHLIG LAGMAGCAIL MTIALALLEQ LPWMSYLSIV AIFGFVAFFE VGPGPIPWFI VAELFSQGPR PAAIAVAGFS NWTSNFIVGM CFQYVEQLCG PYVFIIFTVL LVLFFIFTYF KVPETKGRTF DEIASGFRQG GASQSDKTPE ELFHPLGADS QV
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