About Bcl-2-like protein 2
Bcl-2-like protein 2 (BCL2L2) is a protein
from Homo sapiens identified by UniProt accession
Q92843, 193 residues long.
MolForge cross-references it against 0 known binders and
279 disease associations.
Target properties
| Protein name | Bcl-2-like protein 2 |
|---|
| UniProt accession | Q92843 |
|---|
| Gene | BCL2L2 |
|---|
| Organism | Homo sapiens |
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| Length | 193 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (279)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.55
- oculopharyngeal muscular dystrophy · score 0.44
- primary myelofibrosis · score 0.34
- small cell lung carcinoma · score 0.33
- reticulocyte count · score 0.23
- reticulocyte measurement · score 0.22
- body height · score 0.22
- lymphocyte count · score 0.20
- squamous cell lung carcinoma · score 0.18
- clear cell renal carcinoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92843-F1 | alphafold | PREDICTED | 81.19 | — |
Amino-acid sequence (193 residues)
MATPASAPDT RALVADFVGY KLRQKGYVCG AGPGEGPAAD PLHQAMRAAG DEFETRFRRT FSDLAAQLHV TPGSAQQRFT QVSDELFQGG PNWGRLVAFF VFGAALCAES VNKEMEPLVG QVQEWMVAYL ETQLADWIHS SGGWAEFTAL YGDGALEEAR RLREGNWASV RTVLTGAVAL GALVTVGAFF ASK
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