L-lactate dehydrogenase B chain (LDHB)

About L-lactate dehydrogenase B chain

L-lactate dehydrogenase B chain (LDHB) is a protein from Homo sapiens identified by UniProt accession P07195, 334 residues long. MolForge cross-references it against 0 known binders and 181 disease associations.

Target properties

Protein name	L-lactate dehydrogenase B chain
UniProt accession	P07195
Gene	LDHB
Organism	Homo sapiens
Length	334 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (181)

Diseases linked to this target (Open Targets).

glycogen storage disease due to lactate dehydrogenase H-subunit deficiency · score 0.69
type 2 diabetes mellitus · score 0.35
body height · score 0.31
neoplasm · score 0.11
hepatocellular carcinoma · score 0.10
pulse pressure measurement · score 0.08
non-small cell lung carcinoma · score 0.08
nonpapillary renal cell carcinoma · score 0.08
Merkel cell skin cancer · score 0.08
oral squamous cell carcinoma · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P07195-F1	alphafold	PREDICTED	96.10	—

Amino-acid sequence (334 residues)

MATLKEKLIA PVAEEEATVP NNKITVVGVG QVGMACAISI LGKSLADELA LVDVLEDKLK GEMMDLQHGS LFLQTPKIVA DKDYSVTANS KIVVVTAGVR QQEGESRLNL VQRNVNVFKF IIPQIVKYSP DCIIIVVSNP VDILTYVTWK LSGLPKHRVI GSGCNLDSAR FRYLMAEKLG IHPSSCHGWI LGEHGDSSVA VWSGVNVAGV SLQELNPEMG TDNDSENWKE VHKMVVESAY EVIKLKGYTN WAIGLSVADL IESMLKNLSR IHPVSTMVKG MYGIENEVFL SLPCILNARG LTSVINQKLK DDEVAQLKKS ADTLWDIQKD LKDL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards