Bcl-2-like protein 1 (BCL2L1)

About Bcl-2-like protein 1

Bcl-2-like protein 1 (BCL2L1) is a protein from Homo sapiens identified by UniProt accession Q07817, 233 residues long. MolForge cross-references it against 0 known binders and 867 disease associations.

Target properties

Protein name	Bcl-2-like protein 1
UniProt accession	Q07817
Gene	BCL2L1
Organism	Homo sapiens
Length	233 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (3)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (867)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
severe acute respiratory syndrome · score 0.46
platelet count · score 0.46
platelet crit · score 0.42
eosinophil count · score 0.37
small cell lung carcinoma · score 0.36
primary myelofibrosis · score 0.34
eosinophil percentage of leukocytes · score 0.33
breast adenocarcinoma · score 0.29
head and neck squamous cell carcinoma · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q07817-F1	alphafold	PREDICTED	72.48	—

Amino-acid sequence (233 residues)

MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEG TESEMETPSA INGNPSWHLA DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR YRRAFSDLTS QLHITPGTAY QSFEQVVNEL FRDGVNWGRI VAFFSFGGAL CVESVDKEMQ VLVSRIAAWM ATYLNDHLEP WIQENGGWDT FVELYGNNAA AESRKGQERF NRWFLTGMTV AGVVLLGSLF SRK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards