About Induced myeloid leukemia cell differentiation protein Mcl-1
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) is a protein
from Homo sapiens identified by UniProt accession
Q07820, 350 residues long.
MolForge cross-references it against 0 known binders and
603 disease associations.
Target properties
| Protein name | Induced myeloid leukemia cell differentiation protein Mcl-1 |
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| UniProt accession | Q07820 |
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| Gene | MCL1 |
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| Organism | Homo sapiens |
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| Length | 350 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (603)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.49
- small cell lung carcinoma · score 0.35
- monocyte count · score 0.25
- monocyte percentage of leukocytes · score 0.22
- head and neck squamous cell carcinoma · score 0.21
- breast adenocarcinoma · score 0.21
- vital capacity · score 0.21
- aspartate aminotransferase measurement · score 0.21
- glioblastoma multiforme · score 0.21
- cancer · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q07820-F1 | alphafold | PREDICTED | 63.63 | — |
Amino-acid sequence (350 residues)
MFGLKRNAVI GLNLYCGGAG LGAGSGGATR PGGRLLATEK EASARREIGG GEAGAVIGGS AGASPPSTLT PDSRRVARPP PIGAEVPDVT ATPARLLFFA PTRRAAPLEE MEAPAADAIM SPEEELDGYE PEPLGKRPAV LPLLELVGES GNNTSTDGSL PSTPPPAEEE EDELYRQSLE IISRYLREQA TGAKDTKPMG RSGATSRKAL ETLRRVGDGV QRNHETAFQG MLRKLDIKNE DDVKSLSRVM IHVFSDGVTN WGRIVTLISF GAFVAKHLKT INQESCIEPL AESITDVLVR TKRDWLVKQR GWDGFVEFFH VEDLEGGIRN VLLAFAGVAG VGAGLAYLIR
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