G-protein coupled receptor 55 (GPR55)
Homo sapiens — UniProt Q9Y2T6
Data last refreshed: (UniProt release unknown)
Key facts
G-protein coupled receptor 55 (GPR55) is a protein from Homo sapiens identified by UniProt accession Q9Y2T6, 319 residues long. MolForge cross-references it against 4 known binders and 178 disease associations.
- UniProt accession: Q9Y2T6; gene symbol GPR55.
- Organism: Homo sapiens.
- Length: 319 amino acids.
- Approved drugs acting on it (DrugCentral): Palmidrol and Cannabidiol.
- Top disease associations (Open Targets): ovarian cancer, prostate carcinoma and prostate cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | G-protein coupled receptor 55 |
|---|---|
| UniProt accession | Q9Y2T6 |
| Gene | GPR55 |
| Organism | Homo sapiens |
| Length | 319 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (2)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (178)
Diseases linked to this target (Open Targets).
- ovarian cancer · score 0.23
- prostate carcinoma · score 0.11
- prostate cancer · score 0.11
- Familial prostate cancer · score 0.11
- red blood cell density measurement · score 0.10
- breast adenocarcinoma · score 0.10
- prostate adenocarcinoma · score 0.10
- cholangiocarcinoma · score 0.09
- neoplasm · score 0.08
- atherosclerosis · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2T6-F1 | alphafold | PREDICTED | 87.36 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2T6.
Amino-acid sequence (319 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target GPR55?
DrugCentral lists 2 approved drugs whose mechanism of action is GPR55: Palmidrol and Cannabidiol.
Which diseases are associated with GPR55?
The strongest Open Targets associations for GPR55 are ovarian cancer, prostate carcinoma, prostate cancer, Familial prostate cancer and red blood cell density measurement.
How long is the GPR55 protein?
The Homo sapiens GPR55 protein (UniProt Q9Y2T6) is 319 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2T6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2T6 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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