About Lysophosphatidylserine lipase ABHD12
Lysophosphatidylserine lipase ABHD12 (ABHD12) is a protein
from Homo sapiens identified by UniProt accession
Q8N2K0, 398 residues long.
MolForge cross-references it against 0 known binders and
143 disease associations.
Target properties
| Protein name | Lysophosphatidylserine lipase ABHD12 |
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| UniProt accession | Q8N2K0 |
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| Gene | ABHD12 |
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| Organism | Homo sapiens |
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| Length | 398 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (143)
Diseases linked to this target (Open Targets).
- Polyneuropathy - hearing loss - ataxia - retinitis pigmentosa - cataract · score 0.81
- PHARC syndrome · score 0.78
- Retinal dystrophy · score 0.46
- hearing loss · score 0.46
- hereditary ataxia · score 0.46
- neurodegeneration, childhood-onset, with cerebellar atrophy · score 0.42
- retinitis pigmentosa · score 0.37
- Optic atrophy · score 0.37
- Nystagmus · score 0.37
- Decreased nerve conduction velocity · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N2K0-F1 | alphafold | PREDICTED | 84.84 | — |
Amino-acid sequence (398 residues)
MRKRTEPVAL EHERCAAAGS SSSGSAAAAL DADCRLKQNL RLTGPAAAEP RCAADAGMKR ALGRRKGVWL RLRKILFCVL GLYIAIPFLI KLCPGIQAKL IFLNFVRVPY FIDLKKPQDQ GLNHTCNYYL QPEEDVTIGV WHTVPAVWWK NAQGKDQMWY EDALASSHPI ILYLHGNAGT RGGDHRVELY KVLSSLGYHV VTFDYRGWGD SVGTPSERGM TYDALHVFDW IKARSGDNPV YIWGHSLGTG VATNLVRRLC ERETPPDALI LESPFTNIRE EAKSHPFSVI YRYFPGFDWF FLDPITSSGI KFANDENVKH ISCPLLILHA EDDPVVPFQL GRKLYSIAAP ARSFRDFKVQ FVPFHSDLGY RHKYIYKSPE LPRILREFLG KSEPEHQH
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