About Glycine receptor subunit alpha-3
Glycine receptor subunit alpha-3 (GLRA3) is a protein
from Homo sapiens identified by UniProt accession
O75311, 464 residues long.
MolForge cross-references it against 0 known binders and
110 disease associations.
Target properties
| Protein name | Glycine receptor subunit alpha-3 |
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| UniProt accession | O75311 |
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| Gene | GLRA3 |
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| Organism | Homo sapiens |
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| Length | 464 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (110)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.32
- cutaneous melanoma · score 0.18
- glioblastoma multiforme · score 0.18
- breast carcinoma · score 0.16
- eosinophil count · score 0.14
- lung adenocarcinoma · score 0.12
- squamous cell lung carcinoma · score 0.12
- breast cancer · score 0.11
- excessive daytime sleepiness measurement · score 0.11
- breast adenocarcinoma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75311-F1 | alphafold | PREDICTED | 84.45 | — |
Amino-acid sequence (464 residues)
MAHVRHFRTL VSGFYFWEAA LLLSLVATKE TDSARSRSAP MSPSDFLDKL MGRTSGYDAR IRPNFKGPPV NVTCNIFINS FGSIAETTMD YRVNIFLRQK WNDPRLAYSE YPDDSLDLDP SMLDSIWKPD LFFANEKGAN FHEVTTDNKL LRIFKNGNVL YSIRLTLTLS CPMDLKNFPM DVQTCIMQLE SFGYTMNDLI FEWQDEAPVQ VAEGLTLPQF LLKEEKDLRY CTKHYNTGKF TCIEVRFHLE RQMGYYLIQM YIPSLLIVIL SWVSFWINMD AAPARVALGI TTVLTMTTQS SGSRASLPKV SYVKAIDIWM AVCLLFVFSA LLEYAAVNFV SRQHKELLRF RRKRKNKTEA FALEKFYRFS DMDDEVRESR FSFTAYGMGP CLQAKDGMTP KGPNHPVQVM PKSPDEMRKV FIDRAKKIDT ISRACFPLAF LIFNIFYWVI YKILRHEDIH QQQD
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