Fatty-acid amide hydrolase 1 (FAAH)

About Fatty-acid amide hydrolase 1

Fatty-acid amide hydrolase 1 (FAAH) is a protein from Homo sapiens identified by UniProt accession O00519, 579 residues long. MolForge cross-references it against 0 known binders and 367 disease associations.

Target properties

Protein name	Fatty-acid amide hydrolase 1
UniProt accession	O00519
Gene	FAAH
Organism	Homo sapiens
Length	579 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (7)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (367)

Diseases linked to this target (Open Targets).

migraine disorder · score 0.61
pain · score 0.61
Headache · score 0.61
Fever · score 0.60
common cold · score 0.60
pharyngitis · score 0.60
toothache · score 0.59
Back pain · score 0.58
osteoarthritis · score 0.58
Low back pain · score 0.58

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00519-F1	alphafold	PREDICTED	95.35	—

Amino-acid sequence (579 residues)

MVQYELWAAL PGASGVALAC CFVAAAVALR WSGRRTARGA VVRARQRQRA GLENMDRAAQ RFRLQNPDLD SEALLALPLP QLVQKLHSRE LAPEAVLFTY VGKAWEVNKG TNCVTSYLAD CETQLSQAPR QGLLYGVPVS LKECFTYKGQ DSTLGLSLNE GVPAECDSVV VHVLKLQGAV PFVHTNVPQS MFSYDCSNPL FGQTVNPWKS SKSPGGSSGG EGALIGSGGS PLGLGTDIGG SIRFPSSFCG ICGLKPTGNR LSKSGLKGCV YGQEAVRLSV GPMARDVESL ALCLRALLCE DMFRLDPTVP PLPFREEVYT SSQPLRVGYY ETDNYTMPSP AMRRAVLETK QSLEAAGHTL VPFLPSNIPH ALETLSTGGL FSDGGHTFLQ NFKGDFVDPC LGDLVSILKL PQWLKGLLAF LVKPLLPRLS AFLSNMKSRS AGKLWELQHE IEVYRKTVIA QWRALDLDVV LTPMLAPALD LNAPGRATGA VSYTMLYNCL DFPAGVVPVT TVTAEDEAQM EHYRGYFGDI WDKMLQKGMK KSVGLPVAVQ CVALPWQEEL CLRFMREVER LMTPEKQSS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards