About Cannabinoid receptor 1
Cannabinoid receptor 1 (CNR1) is a protein
from Homo sapiens identified by UniProt accession
P21554, 472 residues long.
MolForge cross-references it against 0 known binders and
685 disease associations.
Target properties
| Protein name | Cannabinoid receptor 1 |
|---|
| UniProt accession | P21554 |
|---|
| Gene | CNR1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 472 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (15)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (685)
Diseases linked to this target (Open Targets).
- obesity · score 0.61
- Lennox-Gastaut syndrome · score 0.53
- pain · score 0.52
- Nausea and vomiting · score 0.50
- epilepsy · score 0.50
- cancer · score 0.49
- Chronic pain · score 0.48
- Seizure · score 0.47
- Nausea · score 0.46
- diabetic neuropathy · score 0.45
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P21554-F1 | alphafold | PREDICTED | 71.70 | — |
Amino-acid sequence (472 residues)
MKSILDGLAD TTFRTITTDL LYVGSNDIQY EDIKGDMASK LGYFPQKFPL TSFRGSPFQE KMTAGDNPQL VPADQVNITE FYNKSLSSFK ENEENIQCGE NFMDIECFMV LNPSQQLAIA VLSLTLGTFT VLENLLVLCV ILHSRSLRCR PSYHFIGSLA VADLLGSVIF VYSFIDFHVF HRKDSRNVFL FKLGGVTASF TASVGSLFLT AIDRYISIHR PLAYKRIVTR PKAVVAFCLM WTIAIVIAVL PLLGWNCEKL QSVCSDIFPH IDETYLMFWI GVTSVLLLFI VYAYMYILWK AHSHAVRMIQ RGTQKSIIIH TSEDGKVQVT RPDQARMDIR LAKTLVLILV VLIICWGPLL AIMVYDVFGK MNKLIKTVFA FCSMLCLLNS TVNPIIYALR SKDLRHAFRS MFPSCEGTAQ PLDNSMGDSD CLHKHANNAA SVHRAAESCI KSTVKIAKVT MSVSTDTSAE AL
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