Cefapirin

ANTIINFECTIVES FOR SYSTEMIC USE

Key facts

Cefapirin is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 1974. DrugCentral lists 22 molecular targets, including SIGMAR1, HTR1A and OPRM1. Recorded indications include Bacterial endocarditis, Bacterial infection due to Klebsiella pneumoniae, Bacterial septicemia and Escherichia coli urinary tract infection.

• Approval status: ofm (first approved 1974 by the FDA).
• Molecular targets: SIGMAR1, HTR1A, OPRM1 and CYP3A4 (22 listed in DrugCentral).
• Indications: Bacterial endocarditis, Bacterial infection due to Klebsiella pneumoniae, Bacterial septicemia, Escherichia coli urinary tract infection and Haemophilus influenzae pneumonia and others.
• ATC code: J01DB08 (First-generation cephalosporins).
• Molecular formula: C17H17N3O6S2; molecular weight 423.47 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (32)

• Bacterial endocarditis
• Bacterial infection due to Klebsiella pneumoniae
• Bacterial septicemia
• Escherichia coli urinary tract infection
• Haemophilus influenzae pneumonia
• Infection due to Escherichia coli
• Infection due to Staphylococcus aureus
• Infection of bone
• Infection of skin AND/OR subcutaneous tissue
• Infectious disorder of joint
• Klebsiella cystitis
• Klebsiella Pneumoniae Osteomyelitis
• Lower respiratory tract infection
• Osteomyelitis due to Staphylococcus aureus
• Pneumonia
• Pneumonia due to Streptococcus
• Prevention of Perioperative Infection
• Proteus Mirabilis Osteomyelitis
• Proteus urinary tract infection
• Rhinoscleroma
• Septicemia due to Escherichia coli
• Skin and Skin Structure Proteus Infection
• Staphylococcal endocarditis
• Staphylococcal pneumonia
• Staphylococcal septicemia
• Staphylococcus Aureus Urinary Tract Infection
• Staphylococcus Epidermidis Skin and Skin Structure Infection
• Streptococcal Endocarditis
• Streptococcal septicemia
• Streptococcus Osteomyelitis
• + 2 more

Mechanism & targets

Molecular targets (22)

Target	Gene	Action	Activity
Sigma non-opioid intracellular receptor 1	SIGMAR1	unknown	IC50 6.21
5-hydroxytryptamine receptor 1A	HTR1A	unknown	IC50 5.48
Mu-type opioid receptor	OPRM1	unknown	IC50 5.34
Cytochrome P450 3A4	CYP3A4	unknown	IC50 5.31
Kappa-type opioid receptor	OPRK1	unknown	IC50 5.29
Histamine H2 receptor	HRH2	unknown	IC50 5.24
Somatostatin receptor type 4	SSTR4	unknown	IC50 5.17
Cytochrome P450 3A5	CYP3A5	unknown	IC50 5.11
Delta-type opioid receptor	OPRD1	unknown	IC50 5.06
D(4) dopamine receptor	DRD4	unknown	IC50 5.01
Substance-P receptor	TACR1	unknown	IC50 4.89
Substance-K receptor	TACR2	unknown	IC50 4.85
Nischarin	NISCH	unknown	IC50 4.85
Cytochrome P450 2D6	CYP2D6	unknown	IC50 4.84
5-hydroxytryptamine receptor 2B	HTR2B	unknown	IC50 4.82
Alpha-2C adrenergic receptor	ADRA2C	unknown	IC50 4.68
D(2) dopamine receptor	DRD2	unknown	IC50 4.66
D(3) dopamine receptor	DRD3	unknown	IC50 4.59
Interstitial collagenase	MMP1	unknown	IC50 4.43
Cannabinoid receptor 1	CNR1	unknown	IC50 4.07

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1974-03-12	FDA	—	APOTHECON

ATC classification

ATC code	Therapeutic hierarchy
J01DB08	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › OTHER BETA-LACTAM ANTIBACTERIALS › First-generation cephalosporins

Chemical structure

• Molecular formula: C₁₇H₁₇N₃O₆S₂
• Molecular weight: 423.47 g/mol
• CAS number: —
• InChIKey: UQLLWWBDSUHNEB-CZUORRHYSA-N
• PubChem CID: 30699

CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)CSC1=CC=NC=C1)C2=O)C(O)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Cefapirin used for?

DrugCentral lists the following indications for Cefapirin: Bacterial endocarditis, Bacterial infection due to Klebsiella pneumoniae, Bacterial septicemia, Escherichia coli urinary tract infection, Haemophilus influenzae pneumonia, Infection due to Escherichia coli, Infection due to Staphylococcus aureus and Infection of bone and others.

How does Cefapirin work?

Its molecular targets in DrugCentral include SIGMAR1, HTR1A, OPRM1 and CYP3A4.

When was Cefapirin first approved?

Cefapirin was first approved by the FDA in 1974.

What is the chemical formula of Cefapirin?

Cefapirin has the molecular formula C17H17N3O6S2 and a molecular weight of 423.47 g/mol.

Sources

• DrugCentral drug card 575 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1201043 — compound record and bioactivity
• PubChem CID 30699 — chemical identifiers
• DrugBank DB01139 — drug record
• FDA UNII 89B59H32VN — substance identity
• DailyMed: FDA labels for Cefapirin — current prescribing information (label search)
• UniProt Q99720 (SIGMAR1) — target protein
• UniProt P08908 (HTR1A) — target protein
• UniProt P35372 (OPRM1) — target protein
• UniProt P08684 (CYP3A4) — target protein
• UniProt P41145 (OPRK1) — target protein
• UniProt P25021 (HRH2) — target protein

How this page is built: methodology · editorial policy & corrections.