Substance-K receptor (TACR2)

About Substance-K receptor

Substance-K receptor (TACR2) is a protein from Homo sapiens identified by UniProt accession P21452, 398 residues long. MolForge cross-references it against 0 known binders and 119 disease associations.

Target properties

Protein name	Substance-K receptor
UniProt accession	P21452
Gene	TACR2
Organism	Homo sapiens
Length	398 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (119)

Diseases linked to this target (Open Targets).

depressive disorder · score 0.40
neurodegenerative disease · score 0.36
anxiety · score 0.35
irritable bowel syndrome · score 0.35
major depressive disorder · score 0.32
ovarian cancer · score 0.26
breast adenocarcinoma · score 0.25
hemoglobin measurement · score 0.17
head and neck squamous cell carcinoma · score 0.16
erythrocyte count · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P21452-F1	alphafold	PREDICTED	79.77	—

Amino-acid sequence (398 residues)

MGTCDIVTEA NISSGPESNT TGITAFSMPS WQLALWATAY LALVLVAVTG NAIVIWIILA HRRMRTVTNY FIVNLALADL CMAAFNAAFN FVYASHNIWY FGRAFCYFQN LFPITAMFVS IYSMTAIAAD RYMAIVHPFQ PRLSAPSTKA VIAGIWLVAL ALASPQCFYS TVTMDQGATK CVVAWPEDSG GKTLLLYHLV VIALIYFLPL AVMFVAYSVI GLTLWRRAVP GHQAHGANLR HLQAMKKFVK TMVLVVLTFA ICWLPYHLYF ILGSFQEDIY CHKFIQQVYL ALFWLAMSST MYNPIIYCCL NHRFRSGFRL AFRCCPWVTP TKEDKLELTP TTSLSTRVNR CHTKETLFMA GDTAPSEATS GEAGRPQDGS GLWFGYGLLA PTKTHVEI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards