Interstitial collagenase (MMP1)

About Interstitial collagenase

Interstitial collagenase (MMP1) is a protein from Homo sapiens identified by UniProt accession P03956, 469 residues long. MolForge cross-references it against 0 known binders and 935 disease associations.

Target properties

Protein name	Interstitial collagenase
UniProt accession	P03956
Gene	MMP1
Organism	Homo sapiens
Length	469 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (10)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (935)

Diseases linked to this target (Open Targets).

acne · score 0.61
Helicobacter pylori infectious disease · score 0.61
rosacea · score 0.60
COVID-19 · score 0.60
periodontitis · score 0.59
infection · score 0.59
Lyme disease · score 0.57
chronic obstructive pulmonary disease · score 0.57
Borrelia infectious disease · score 0.56
ulcerative colitis · score 0.56

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P03956-F1	alphafold	PREDICTED	91.22	—

Amino-acid sequence (469 residues)

MHSFPPLLLL LFWGVVSHSF PATLETQEQD VDLVQKYLEK YYNLKNDGRQ VEKRRNSGPV VEKLKQMQEF FGLKVTGKPD AETLKVMKQP RCGVPDVAQF VLTEGNPRWE QTHLTYRIEN YTPDLPRADV DHAIEKAFQL WSNVTPLTFT KVSEGQADIM ISFVRGDHRD NSPFDGPGGN LAHAFQPGPG IGGDAHFDED ERWTNNFREY NLHRVAAHEL GHSLGLSHST DIGALMYPSY TFSGDVQLAQ DDIDGIQAIY GRSQNPVQPI GPQTPKACDS KLTFDAITTI RGEVMFFKDR FYMRTNPFYP EVELNFISVF WPQLPNGLEA AYEFADRDEV RFFKGNKYWA VQGQNVLHGY PKDIYSSFGF PRTVKHIDAA LSEENTGKTY FFVANKYWRY DEYKRSMDPG YPKMIAHDFP GIGHKVDAVF MKDGFFYFFH GTRQYKFDPK TKRILTLQKA NSWFNCRKN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards