Kappa-type opioid receptor (OPRK1)

About Kappa-type opioid receptor

Kappa-type opioid receptor (OPRK1) is a protein from Homo sapiens identified by UniProt accession P41145, 380 residues long. MolForge cross-references it against 0 known binders and 330 disease associations.

Target properties

Protein name	Kappa-type opioid receptor
UniProt accession	P41145
Gene	OPRK1
Organism	Homo sapiens
Length	380 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (330)

Diseases linked to this target (Open Targets).

alcohol dependence · score 0.61
pain · score 0.61
opioid dependence · score 0.61
migraine disorder · score 0.60
drug dependence · score 0.60
opioid use disorder · score 0.60
Chronic pain · score 0.59
heroin dependence · score 0.58
osteoarthritis · score 0.57
unipolar depression · score 0.57

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P41145-F1	alphafold	PREDICTED	79.53	—

Amino-acid sequence (380 residues)

MDSPIQIFRG EPGPTCAPSA CLPPNSSAWF PGWAEPDSNG SAGSEDAQLE PAHISPAIPV IITAVYSVVF VVGLVGNSLV MFVIIRYTKM KTATNIYIFN LALADALVTT TMPFQSTVYL MNSWPFGDVL CKIVISIDYY NMFTSIFTLT MMSVDRYIAV CHPVKALDFR TPLKAKIINI CIWLLSSSVG ISAIVLGGTK VREDVDVIEC SLQFPDDDYS WWDLFMKICV FIFAFVIPVL IIIVCYTLMI LRLKSVRLLS GSREKDRNLR RITRLVLVVV AVFVVCWTPI HIFILVEALG STSHSTAALS SYYFCIALGY TNSSLNPILY AFLDENFKRC FRDFCFPLKM RMERQSTSRV RNTVQDPAYL RDIDGMNKPV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards