Nischarin (NISCH)
Homo sapiens — UniProt Q9Y2I1
Data last refreshed: (UniProt release unknown)
Key facts
Nischarin (NISCH) is a protein from Homo sapiens identified by UniProt accession Q9Y2I1, 1504 residues long. MolForge cross-references it against 12 known binders and 162 disease associations.
- UniProt accession: Q9Y2I1; gene symbol NISCH.
- Organism: Homo sapiens.
- Length: 1504 amino acids.
- Approved drugs acting on it (DrugCentral): Moxonidine.
- Top disease associations (Open Targets): hypertension, Parkinson disease and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nischarin |
|---|---|
| UniProt accession | Q9Y2I1 |
| Gene | NISCH |
| Organism | Homo sapiens |
| Length | 1504 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (1)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (162)
Diseases linked to this target (Open Targets).
- hypertension · score 0.49
- Parkinson disease · score 0.43
- neurodegenerative disease · score 0.43
- lysosomal storage disease · score 0.43
- multiple sclerosis · score 0.43
- Alzheimer disease · score 0.43
- schizophrenia · score 0.37
- nervous system disease · score 0.37
- polycystic ovary syndrome · score 0.37
- diabetic nephropathy · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2I1-F1 | alphafold | PREDICTED | 68.81 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2I1.
Amino-acid sequence (1504 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target NISCH?
DrugCentral lists 1 approved drug whose mechanism of action is NISCH: Moxonidine.
Which diseases are associated with NISCH?
The strongest Open Targets associations for NISCH are hypertension, Parkinson disease, neurodegenerative disease, lysosomal storage disease and multiple sclerosis.
How long is the NISCH protein?
The Homo sapiens NISCH protein (UniProt Q9Y2I1) is 1504 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2I1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2I1 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.