Delta-type opioid receptor (OPRD1)

About Delta-type opioid receptor

Delta-type opioid receptor (OPRD1) is a protein from Homo sapiens identified by UniProt accession P41143, 372 residues long. MolForge cross-references it against 0 known binders and 223 disease associations.

Target properties

Protein name	Delta-type opioid receptor
UniProt accession	P41143
Gene	OPRD1
Organism	Homo sapiens
Length	372 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (223)

Diseases linked to this target (Open Targets).

pain · score 0.61
alcohol dependence · score 0.60
opioid dependence · score 0.60
migraine disorder · score 0.60
drug dependence · score 0.60
Chronic pain · score 0.59
opioid use disorder · score 0.58
obesity · score 0.56
Constipation · score 0.55
heroin dependence · score 0.55

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P41143-F1	alphafold	PREDICTED	80.01	—

Amino-acid sequence (372 residues)

MEPAPSAGAE LQPPLFANAS DAYPSACPSA GANASGPPGA RSASSLALAI AITALYSAVC AVGLLGNVLV MFGIVRYTKM KTATNIYIFN LALADALATS TLPFQSAKYL METWPFGELL CKAVLSIDYY NMFTSIFTLT MMSVDRYIAV CHPVKALDFR TPAKAKLINI CIWVLASGVG VPIMVMAVTR PRDGAVVCML QFPSPSWYWD TVTKICVFLF AFVVPILIIT VCYGLMLLRL RSVRLLSGSK EKDRSLRRIT RMVLVVVGAF VVCWAPIHIF VIVWTLVDID RRDPLVVAAL HLCIALGYAN SSLNPVLYAF LDENFKRCFR QLCRKPCGRP DPSSFSRARE ATARERVTAC TPSDGPGGGA AA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards