Cytochrome P450 3A4 (CYP3A4)

About Cytochrome P450 3A4

Cytochrome P450 3A4 (CYP3A4) is a protein from Homo sapiens identified by UniProt accession P08684, 503 residues long. MolForge cross-references it against 0 known binders and 550 disease associations.

Target properties

Protein name	Cytochrome P450 3A4
UniProt accession	P08684
Gene	CYP3A4
Organism	Homo sapiens
Length	503 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (550)

Diseases linked to this target (Open Targets).

HIV infection · score 0.61
HIV-1 infection · score 0.60
COVID-19 · score 0.59
AIDS · score 0.58
chronic hepatitis C virus infection · score 0.57
infection · score 0.56
hepatitis C virus infection · score 0.55
HIV-Associated Lipodystrophy Syndrome · score 0.46
coronavirus infectious disease · score 0.44
cancer · score 0.42

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P08684-F1	alphafold	PREDICTED	92.40	—

Amino-acid sequence (503 residues)

MALIPDLAME TWLLLAVSLV LLYLYGTHSH GLFKKLGIPG PTPLPFLGNI LSYHKGFCMF DMECHKKYGK VWGFYDGQQP VLAITDPDMI KTVLVKECYS VFTNRRPFGP VGFMKSAISI AEDEEWKRLR SLLSPTFTSG KLKEMVPIIA QYGDVLVRNL RREAETGKPV TLKDVFGAYS MDVITSTSFG VNIDSLNNPQ DPFVENTKKL LRFDFLDPFF LSITVFPFLI PILEVLNICV FPREVTNFLR KSVKRMKESR LEDTQKHRVD FLQLMIDSQN SKETESHKAL SDLELVAQSI IFIFAGYETT SSVLSFIMYE LATHPDVQQK LQEEIDAVLP NKAPPTYDTV LQMEYLDMVV NETLRLFPIA MRLERVCKKD VEINGMFIPK GVVVMIPSYA LHRDPKYWTE PEKFLPERFS KKNKDNIDPY IYTPFGSGPR NCIGMRFALM NMKLALIRVL QNFSFKPCKE TQIPLKLSLG GLLQPEKPVV LKVESRDGTV SGA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards