Cycloserine

ANTIINFECTIVES FOR SYSTEMIC USE

Key facts

Cycloserine is an ofp drug catalogued in DrugCentral. It was first approved by the FDA in 1964. DrugCentral lists 14 molecular targets, including Grin1|Grin2a|Grin2b|Grin2c|Grin2d|Grin3b|Grin3a, GRIN3A and GRIN2B. Recorded indications include Acute tuberculosis, Bacterial urinary infection, Escherichia coli urinary tract infection and Pulmonary tuberculosis.

• Approval status: ofp (first approved 1964 by the FDA).
• Molecular targets: Grin1|Grin2a|Grin2b|Grin2c|Grin2d|Grin3b|Grin3a, GRIN3A, GRIN2B and GRIN2D (14 listed in DrugCentral).
• Indications: Acute tuberculosis, Bacterial urinary infection, Escherichia coli urinary tract infection and Pulmonary tuberculosis.
• ATC code: J04AB01 (Antibiotics).
• Molecular formula: C3H6N2O2; molecular weight 102.09 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (4)

• Acute tuberculosis
• Bacterial urinary infection
• Escherichia coli urinary tract infection
• Pulmonary tuberculosis

Off-label uses (2)

• Mycobacteriosis
• Tuberculosis of meninges

Contraindications (12)

• Acute nephropathy
• Alcoholism
• CNS Toxicity
• Cobalamin deficiency
• Depressive disorder
• Epilepsy
• Folic acid deficiency
• Kidney disease
• Megaloblastic anemia
• Psychotic disorder
• Severe anxiety (panic)
• Sideroblastic anemia

Mechanism & targets

Molecular targets (14)

Target	Gene	Action	Activity
Glutamate NMDA receptor	Grin1|Grin2a|Grin2b|Grin2c|Grin2d|Grin3b|Grin3a	unknown	IC50 5.64
Glutamate receptor ionotropic, NMDA 3A	GRIN3A	unknown	IC50 5.64
Glutamate receptor ionotropic, NMDA 2B	GRIN2B	unknown	IC50 5.64
Glutamate receptor ionotropic, NMDA 2D	GRIN2D	unknown	IC50 5.64
Glutamate receptor ionotropic, NMDA 3B	GRIN3B	unknown	IC50 5.64
Glutamate receptor ionotropic, NMDA 2A	GRIN2A	unknown	IC50 5.64
Glutamate receptor ionotropic, NMDA 2C	GRIN2C	unknown	IC50 5.34
Glutamate receptor ionotropic, NMDA 1	GRIN1	unknown	IC50 5.26
Glutamate receptor ionotropic, NMDA 1	Grin1	unknown	IC50 5.13
Glutamate receptor ionotropic, NMDA 2C	Grin2c	unknown	EC50 4.74
Cytochrome P450 3A4	CYP3A4	unknown	IC50 4.31
D-alanine--D-alanine ligase	ddl	inhibitor	—
Alanine racemase	alr	unknown	—
Alanine racemase	alr	inhibitor	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1964-06-29	FDA	—	PURDUE GMP

ATC classification

ATC code	Therapeutic hierarchy
J04AB01	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIMYCOBACTERIALS › DRUGS FOR TREATMENT OF TUBERCULOSIS › Antibiotics

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Electrocardiogram QT prolonged	830.9
Neuropathy peripheral	433.7
Drug resistance	313.1
Hepatotoxicity	256.3
Anaemia	195.5
Optic neuritis	174.5
Optic neuropathy	166.3
Drug reaction with eosinophilia and systemic symptoms	138.4
Off label use	116.0
Toxic optic neuropathy	93.3
Ototoxicity	85.5
Psychotic disorder	68.0

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Cycloserine is on its molecule page.

• Molecular formula: C₃H₆N₂O₂
• Molecular weight: 102.09 g/mol
• CAS number: —
• InChIKey: DYDCUQKUCUHJBH-UWTATZPHSA-N
• PubChem CID: 6234

N[C@@H]1CONC1=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Cycloserine used for?

DrugCentral lists the following indications for Cycloserine: Acute tuberculosis, Bacterial urinary infection, Escherichia coli urinary tract infection and Pulmonary tuberculosis.

How does Cycloserine work?

Its molecular targets in DrugCentral include Grin1|Grin2a|Grin2b|Grin2c|Grin2d|Grin3b|Grin3a, GRIN3A, GRIN2B and GRIN2D.

When was Cycloserine first approved?

Cycloserine was first approved by the FDA in 1964.

What is the chemical formula of Cycloserine?

Cycloserine has the molecular formula C3H6N2O2 and a molecular weight of 102.09 g/mol.

Sources

• DrugCentral drug card 759 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL771 — compound record and bioactivity
• PubChem CID 6234 — chemical identifiers
• DrugBank DB00260 — drug record
• FDA UNII 95IK5KI84Z — substance identity
• DailyMed: FDA labels for Cycloserine — current prescribing information (label search)
• UniProt Q8TCU5 (GRIN3A) — target protein
• UniProt Q13224 (GRIN2B) — target protein
• UniProt O15399 (GRIN2D) — target protein
• UniProt O60391 (GRIN3B) — target protein
• UniProt Q12879 (GRIN2A) — target protein
• UniProt Q14957 (GRIN2C) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.