Rifamycin

Rifamycin Antibacterial — ALIMENTARY TRACT AND METABOLISM

Key facts

Rifamycin is an ofm drug in the Rifamycin Antibacterial class catalogued in DrugCentral. It was first approved by the FDA in 2018. DrugCentral lists 5 molecular targets, including SLCO1B1, Abcb11 and ABCB11. Recorded indications include Traveler's diarrhea.

• Approval status: ofm (first approved 2018 by the FDA).
• Drug class: Rifamycin Antibacterial.
• Molecular targets: SLCO1B1, Abcb11, ABCB11 and SLCO1A2 (5 listed in DrugCentral).
• Indications: Traveler's diarrhea.
• ATC code: A07AA13 (Antibiotics).
• Molecular formula: C37H47NO12; molecular weight 697.78 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Traveler's diarrhea

Mechanism & targets

• Established pharmacologic class: Rifamycin Antibacterial

Molecular targets (5)

Target	Gene	Action	Activity
Solute carrier organic anion transporter family member 1B1	SLCO1B1	inhibitor	Ki 5.70
Bile salt export pump	Abcb11	unknown	IC50 5.51
Bile salt export pump	ABCB11	unknown	IC50 5.20
Solute carrier organic anion transporter family member 1A2	SLCO1A2	inhibitor	Ki 4.96
DNA-directed RNA polymerase subunit beta	rpoB	inhibitor	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2018-11-16	FDA	—	COSMO TECHNOLOGIES

ATC classification

ATC code	Therapeutic hierarchy
A07AA13	ALIMENTARY TRACT AND METABOLISM › ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS › INTESTINAL ANTIINFECTIVES › Antibiotics
D06AX15	DERMATOLOGICALS › ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE › ANTIBIOTICS FOR TOPICAL USE › Other antibiotics for topical use
J04AB03	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIMYCOBACTERIALS › DRUGS FOR TREATMENT OF TUBERCULOSIS › Antibiotics
S01AA16	SENSORY ORGANS › OPHTHALMOLOGICALS › ANTIINFECTIVES › Antibiotics
S02AA12	SENSORY ORGANS › OTOLOGICALS › ANTIINFECTIVES › Antiinfectives

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Polyglandular disorder	82.3

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Rifamycin is on its molecule page.

• Molecular formula: C₃₇H₄₇NO₁₂
• Molecular weight: 697.78 g/mol
• CAS number: 6998-60-3
• InChIKey: HJYYPODYNSCCOU-ODRIEIDWSA-N
• PubChem CID: 6324616

CO[C@H]1\C=C\O[C@@]2(C)OC3=C(C)C(O)=C4C(O)=C(NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)C=C(O)C4=C3C2=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Rifamycin used for?

DrugCentral lists the following indications for Rifamycin: Traveler's diarrhea.

How does Rifamycin work?

Its molecular targets in DrugCentral include SLCO1B1 (inhibitor), Abcb11, ABCB11 and SLCO1A2 (inhibitor).

When was Rifamycin first approved?

Rifamycin was first approved by the FDA in 2018.

What drug class does Rifamycin belong to?

Rifamycin is in the Rifamycin Antibacterial class.

What is the chemical formula of Rifamycin?

Rifamycin has the molecular formula C37H47NO12 and a molecular weight of 697.78 g/mol.

Sources

• DrugCentral drug card 4817 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL2105680 — compound record and bioactivity
• PubChem CID 6324616 — chemical identifiers
• DrugBank DB11753 — drug record
• FDA UNII DU69T8ZZPA — substance identity
• DailyMed: FDA labels for Rifamycin — current prescribing information (label search)
• UniProt Q9Y6L6 (SLCO1B1) — target protein
• UniProt O95342 (ABCB11) — target protein
• UniProt P46721 (SLCO1A2) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.