Solute carrier organic anion transporter family member 1B1 (SLCO1B1)
Homo sapiens — UniProt Q9Y6L6
Data last refreshed: (UniProt release unknown)
Key facts
Solute carrier organic anion transporter family member 1B1 (SLCO1B1) is a protein from Homo sapiens identified by UniProt accession Q9Y6L6, 691 residues long. MolForge cross-references it against 5 known binders and 322 disease associations.
- UniProt accession: Q9Y6L6; gene symbol SLCO1B1.
- Organism: Homo sapiens.
- Length: 691 amino acids.
- Target class: Transporter.
- Approved drugs acting on it (DrugCentral): Ciclosporin, Rifampicin and Rifamycin.
- Top disease associations (Open Targets): bilirubin measurement, Rotor syndrome and serum metabolite measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Solute carrier organic anion transporter family member 1B1 |
|---|---|
| UniProt accession | Q9Y6L6 |
| Gene | SLCO1B1 |
| Organism | Homo sapiens |
| Length | 691 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Transporter (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (3)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (322)
Diseases linked to this target (Open Targets).
- bilirubin measurement · score 0.72
- Rotor syndrome · score 0.57
- serum metabolite measurement · score 0.52
- sex hormone-binding globulin measurement · score 0.51
- blood metabolite measurement · score 0.51
- mean corpuscular volume · score 0.49
- urinary metabolite measurement · score 0.49
- vitamin D measurement · score 0.49
- testosterone measurement · score 0.48
- triglyceride measurement · score 0.48
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y6L6-F1 | alphafold | PREDICTED | 80.27 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y6L6.
Amino-acid sequence (691 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target SLCO1B1?
DrugCentral lists 3 approved drugs whose mechanism of action is SLCO1B1: Ciclosporin, Rifampicin and Rifamycin.
Which diseases are associated with SLCO1B1?
The strongest Open Targets associations for SLCO1B1 are bilirubin measurement, Rotor syndrome, serum metabolite measurement, sex hormone-binding globulin measurement and blood metabolite measurement.
How long is the SLCO1B1 protein?
The Homo sapiens SLCO1B1 protein (UniProt Q9Y6L6) is 691 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y6L6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y6L6 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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