Bacitracin

DERMATOLOGICALS

Key facts

Bacitracin is a drug catalogued in DrugCentral. It was first approved by the FDA in 1948. DrugCentral lists 4 molecular targets, including Htr1b, LCK and EGFR. Recorded indications include Bacterial keratitis, Blepharoconjunctivitis, Corneal abrasion and Infective blepharitis.

• Molecular targets: Htr1b, LCK, EGFR and uppP (4 listed in DrugCentral).
• Indications: Bacterial keratitis, Blepharoconjunctivitis, Corneal abrasion, Infective blepharitis and Keratitis and others.
• ATC code: D06AX05 (Other antibiotics for topical use).
• Molecular formula: C261H406N68O64S4; molecular weight 5648.77 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (7)

• Bacterial keratitis
• Blepharoconjunctivitis
• Corneal abrasion
• Infective blepharitis
• Keratitis
• Minor Bacterial Skin Infections
• Superficial Ocular Infection

Off-label uses (4)

• Bacterial conjunctivitis
• Corneal ulcer
• Dacryocystitis
• Meibomianitis

Contraindications (31)

• Adrenal cortical hypofunction
• Atrophoderma
• Bacterial infection of eye
• Bacterial septicemia
• Decreased respiratory function
• Denuded skin
• Diabetes mellitus
• Disease of liver
• Eye infection
• Fungal infection of eye
• Heart block
• Herpes simplex dendritic keratitis
• Herpes simplex keratitis
• Injury of eye region
• Kidney disease
• Krukenberg spindle
• Myasthenia gravis
• Ocular hypertension
• Oliguria
• Open wound
• Open-angle glaucoma
• Peripheral vascular disease
• Pregnancy, function
• Seizure disorder
• Severe myopia
• Shock
• Telangiectasia disorder
• Third degree burn injury
• Tuberculosis of eye
• Vaccinia keratitis
• + 1 more

Mechanism & targets

Molecular targets (4)

Target	Gene	Action	Activity
5-hydroxytryptamine receptor 1B	Htr1b	unknown	Ki 5.87
Tyrosine-protein kinase Lck	LCK	unknown	IC50 5.72
Epidermal growth factor receptor	EGFR	unknown	IC50 5.27
Undecaprenyl-diphosphatase	uppP	unknown	IC50 5.25

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1948-07-29	FDA	—	PHARMACIA AND UPJOHN

ATC classification

ATC code	Therapeutic hierarchy
D06AX05	DERMATOLOGICALS › ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE › ANTIBIOTICS FOR TOPICAL USE › Other antibiotics for topical use
J01XX10	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › OTHER ANTIBACTERIALS › Other antibacterials
R02AB04	RESPIRATORY SYSTEM › THROAT PREPARATIONS › THROAT PREPARATIONS › Antibiotics
S01AA32	SENSORY ORGANS › OPHTHALMOLOGICALS › ANTIINFECTIVES › Antibiotics

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Local anaesthetic systemic toxicity	1870.4
Anaphylactic reaction	542.1
Anaphylactic shock	534.0
Cardiac arrest	498.6
Methaemoglobinaemia	460.4
Toxic anterior segment syndrome	358.7
Maternal exposure during delivery	338.4
Hypotension	315.1
Generalised tonic-clonic seizure	292.5
Pemphigus	280.3
Hand deformity	274.2
Systemic lupus erythematosus	271.8

Chemical structure

• Molecular formula: C₂₆₁H₄₀₆N₆₈O₆₄S₄
• Molecular weight: 5648.77 g/mol
• CAS number: 1405-87-4
• InChIKey: —
• PubChem CID: 10909430

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Bacitracin used for?

DrugCentral lists the following indications for Bacitracin: Bacterial keratitis, Blepharoconjunctivitis, Corneal abrasion, Infective blepharitis, Keratitis, Minor Bacterial Skin Infections and Superficial Ocular Infection.

How does Bacitracin work?

Its molecular targets in DrugCentral include Htr1b, LCK, EGFR and uppP.

When was Bacitracin first approved?

Bacitracin was first approved by the FDA in 1948.

What is the chemical formula of Bacitracin?

Bacitracin has the molecular formula C261H406N68O64S4 and a molecular weight of 5648.77 g/mol.

Sources

• DrugCentral drug card 281 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200558 — compound record and bioactivity
• PubChem CID 10909430 — chemical identifiers
• DrugBank DB00626 — drug record
• FDA UNII 58H6RWO52I — substance identity
• DailyMed: FDA labels for Bacitracin — current prescribing information (label search)
• UniProt P06239 (LCK) — target protein
• UniProt P00533 (EGFR) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.