About Tyrosine-protein kinase Lck
Tyrosine-protein kinase Lck (LCK) is a protein
from Homo sapiens identified by UniProt accession
P06239, 509 residues long.
MolForge cross-references it against 0 known binders and
615 disease associations.
Target properties
| Protein name | Tyrosine-protein kinase Lck |
|---|
| UniProt accession | P06239 |
|---|
| Gene | LCK |
|---|
| Organism | Homo sapiens |
|---|
| Length | 509 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (615)
Diseases linked to this target (Open Targets).
- severe combined immunodeficiency due to LCK deficiency · score 0.74
- cancer · score 0.68
- acute lymphoblastic leukemia · score 0.60
- chronic myelogenous leukemia · score 0.58
- renal cell carcinoma · score 0.58
- sarcoma · score 0.56
- soft tissue sarcoma · score 0.50
- neoplasm · score 0.48
- HIV infection · score 0.48
- combined immunodeficiency · score 0.46
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P06239-F1 | alphafold | PREDICTED | 83.59 | — |
Amino-acid sequence (509 residues)
MGCGCSSHPE DDWMENIDVC ENCHYPIVPL DGKGTLLIRN GSEVRDPLVT YEGSNPPASP LQDNLVIALH SYEPSHDGDL GFEKGEQLRI LEQSGEWWKA QSLTTGQEGF IPFNFVAKAN SLEPEPWFFK NLSRKDAERQ LLAPGNTHGS FLIRESESTA GSFSLSVRDF DQNQGEVVKH YKIRNLDNGG FYISPRITFP GLHELVRHYT NASDGLCTRL SRPCQTQKPQ KPWWEDEWEV PRETLKLVER LGAGQFGEVW MGYYNGHTKV AVKSLKQGSM SPDAFLAEAN LMKQLQHQRL VRLYAVVTQE PIYIITEYME NGSLVDFLKT PSGIKLTINK LLDMAAQIAE GMAFIEERNY IHRDLRAANI LVSDTLSCKI ADFGLARLIE DNEYTAREGA KFPIKWTAPE AINYGTFTIK SDVWSFGILL TEIVTHGRIP YPGMTNPEVI QNLERGYRMV RPDNCPEELY QLMRLCWKER PEDRPTFDYL RSVLEDFFTA TEGQYQPQP
Explore Tyrosine-protein kinase Lck with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets