Solute carrier organic anion transporter family member 1A2 (SLCO1A2)
Homo sapiens — UniProt P46721
Data last refreshed: (UniProt release unknown)
Key facts
Solute carrier organic anion transporter family member 1A2 (SLCO1A2) is a protein from Homo sapiens identified by UniProt accession P46721, 670 residues long. MolForge cross-references it against 3 known binders and 170 disease associations.
- UniProt accession: P46721; gene symbol SLCO1A2.
- Organism: Homo sapiens.
- Length: 670 amino acids.
- Target class: Transporter.
- Approved drugs acting on it (DrugCentral): Rifamycin and Rifampicin.
- Top disease associations (Open Targets): serum metabolite measurement, cortical thickness and lean body mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Solute carrier organic anion transporter family member 1A2 |
|---|---|
| UniProt accession | P46721 |
| Gene | SLCO1A2 |
| Organism | Homo sapiens |
| Length | 670 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Transporter (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (2)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (170)
Diseases linked to this target (Open Targets).
- serum metabolite measurement · score 0.29
- cortical thickness · score 0.28
- lean body mass · score 0.28
- blood protein measurement · score 0.25
- response to neuromuscular blocker · score 0.25
- cutaneous melanoma · score 0.24
- fat body mass · score 0.23
- progressive supranuclear palsy · score 0.23
- serum gamma-glutamyl transferase measurement · score 0.21
- whole body water mass · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P46721-F1 | alphafold | PREDICTED | 80.17 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P46721.
Amino-acid sequence (670 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target SLCO1A2?
DrugCentral lists 2 approved drugs whose mechanism of action is SLCO1A2: Rifamycin and Rifampicin.
Which diseases are associated with SLCO1A2?
The strongest Open Targets associations for SLCO1A2 are serum metabolite measurement, cortical thickness, lean body mass, blood protein measurement and response to neuromuscular blocker.
How long is the SLCO1A2 protein?
The Homo sapiens SLCO1A2 protein (UniProt P46721) is 670 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P46721 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P46721 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.