Glutamate receptor ionotropic, NMDA 1 (GRIN1)

About Glutamate receptor ionotropic, NMDA 1

Glutamate receptor ionotropic, NMDA 1 (GRIN1) is a protein from Homo sapiens identified by UniProt accession Q05586, 938 residues long. MolForge cross-references it against 0 known binders and 452 disease associations.

Target properties

Protein name	Glutamate receptor ionotropic, NMDA 1
UniProt accession	Q05586
Gene	GRIN1
Organism	Homo sapiens
Length	938 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (452)

Diseases linked to this target (Open Targets).

neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant · score 0.85
intellectual disability, autosomal dominant 8 · score 0.82
Parkinson disease · score 0.69
Alzheimer disease · score 0.69
pain · score 0.60
infection · score 0.60
influenza · score 0.60
depressive disorder · score 0.60
major depressive disorder · score 0.60
multiple sclerosis · score 0.59

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q05586-F1	alphafold	PREDICTED	82.86	—

Amino-acid sequence (938 residues)

MSTMRLLTLA LLFSCSVARA ACDPKIVNIG AVLSTRKHEQ MFREAVNQAN KRHGSWKIQL NATSVTHKPN AIQMALSVCE DLISSQVYAI LVSHPPTPND HFTPTPVSYT AGFYRIPVLG LTTRMSIYSD KSIHLSFLRT VPPYSHQSSV WFEMMRVYSW NHIILLVSDD HEGRAAQKRL ETLLEERESK AEKVLQFDPG TKNVTALLME AKELEARVII LSASEDDAAT VYRAAAMLNM TGSGYVWLVG EREISGNALR YAPDGILGLQ LINGKNESAH ISDAVGVVAQ AVHELLEKEN ITDPPRGCVG NTNIWKTGPL FKRVLMSSKY ADGVTGRVEF NEDGDRKFAN YSIMNLQNRK LVQVGIYNGT HVIPNDRKII WPGGETEKPR GYQMSTRLKI VTIHQEPFVY VKPTLSDGTC KEEFTVNGDP VKKVICTGPN DTSPGSPRHT VPQCCYGFCI DLLIKLARTM NFTYEVHLVA DGKFGTQERV NNSNKKEWNG MMGELLSGQA DMIVAPLTIN NERAQYIEFS KPFKYQGLTI LVKKEIPRST LDSFMQPFQS TLWLLVGLSV HVVAVMLYLL DRFSPFGRFK VNSEEEEEDA LTLSSAMWFS WGVLLNSGIG EGAPRSFSAR ILGMVWAGFA MIIVASYTAN LAAFLVLDRP EERITGINDP RLRNPSDKFI YATVKQSSVD IYFRRQVELS TMYRHMEKHN YESAAEAIQA VRDNKLHAFI WDSAVLEFEA SQKCDLVTTG ELFFRSGFGI GMRKDSPWKQ NVSLSILKSH ENGFMEDLDK TWVRYQECDS RSNAPATLTF ENMAGVFMLV AGGIVAGIFL IFIEIAYKRH KDARRKQMQL AFAAVNVWRK NLQDRKSGRA EPDPKKKATF RAITSTLASS FKRRRSSKDT STGGGRGALQ NQKDTVLPRR AIEREEGQLQ LCSRHRES

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards