About Glutamate receptor ionotropic, NMDA 2C
Glutamate receptor ionotropic, NMDA 2C (GRIN2C) is a protein
from Homo sapiens identified by UniProt accession
Q14957, 1233 residues long.
MolForge cross-references it against 0 known binders and
241 disease associations.
Target properties
| Protein name | Glutamate receptor ionotropic, NMDA 2C |
|---|
| UniProt accession | Q14957 |
|---|
| Gene | GRIN2C |
|---|
| Organism | Homo sapiens |
|---|
| Length | 1233 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (241)
Diseases linked to this target (Open Targets).
- Parkinson disease · score 0.61
- pain · score 0.60
- influenza · score 0.60
- infection · score 0.60
- Alzheimer disease · score 0.60
- depressive disorder · score 0.60
- major depressive disorder · score 0.60
- alcohol dependence · score 0.59
- Dementia · score 0.59
- postencephalitic Parkinson disease · score 0.58
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14957-F1 | alphafold | PREDICTED | 67.47 | — |
Amino-acid sequence (1233 residues)
MGGALGPALL LTSLFGAWAG LGPGQGEQGM TVAVVFSSSG PPQAQFRARL TPQSFLDLPL EIQPLTVGVN TTNPSSLLTQ ICGLLGAAHV HGIVFEDNVD TEAVAQILDF ISSQTHVPIL SISGGSAVVL TPKEPGSAFL QLGVSLEQQL QVLFKVLEEY DWSAFAVITS LHPGHALFLE GVRAVADASH VSWRLLDVVT LELGPGGPRA RTQRLLRQLD APVFVAYCSR EEAEVLFAEA AQAGLVGPGH VWLVPNLALG STDAPPATFP VGLISVVTES WRLSLRQKVR DGVAILALGA HSYWRQHGTL PAPAGDCRVH PGPVSPAREA FYRHLLNVTW EGRDFSFSPG GYLVQPTMVV IALNRHRLWE MVGRWEHGVL YMKYPVWPRY SASLQPVVDS RHLTVATLEE RPFVIVESPD PGTGGCVPNT VPCRRQSNHT FSSGDVAPYT KLCCKGFCID ILKKLARVVK FSYDLYLVTN GKHGKRVRGV WNGMIGEVYY KRADMAIGSL TINEERSEIV DFSVPFVETG ISVMVARSNG TVSPSAFLEP YSPAVWVMMF VMCLTVVAIT VFMFEYFSPV SYNQNLTRGK KSGGPAFTIG KSVWLLWALV FNNSVPIENP RGTTSKIMVL VWAFFAVIFL ASYTANLAAF MIQEQYIDTV SGLSDKKFQR PQDQYPPFRF GTVPNGSTER NIRSNYRDMH THMVKFNQRS VEDALTSLKM GKLDAFIYDA AVLNYMAGKD EGCKLVTIGS GKVFATTGYG IAMQKDSHWK RAIDLALLQF LGDGETQKLE TVWLSGICQN EKNEVMSSKL DIDNMAGVFY MLLVAMGLAL LVFAWEHLVY WKLRHSVPNS SQLDFLLAFS RGIYSCFSGV QSLASPPRQA SPDLTASSAQ ASVLKMLQAA RDMVTTAGVS SSLDRATRTI ENWGGGRRAP PPSPCPTPRS GPSPCLPTPD PPPEPSPTGW GPPDGGRAAL VRRAPQPPGR PPTPGPPLSD VSRVSRRPAW EARWPVRTGH CGRHLSASER PLSPARCHYS SFPRADRSGR PFLPLFPELE DLPLLGPEQL ARREALLHAA WARGSRPRHA SLPSSVAEAF ARPSSLPAGC TGPACARPDG HSACRRLAQA QSMCLPIYRE ACQEGEQAGA PAWQHRQHVC LHAHAHLPFC WGAVCPHLPP CASHGSWLSG AWGPLGHRGR TLGLGTGYRD SGGLDEISRV ARGTQGFPGP CTWRRISSLE SEV
Explore Glutamate receptor ionotropic, NMDA 2C with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets