Ifenprodil

CARDIOVASCULAR SYSTEM

Key facts

Ifenprodil is a drug catalogued in DrugCentral. DrugCentral lists 19 molecular targets, including Tspo, SIGMAR1 and Sigmar1.

• Molecular targets: Tspo, SIGMAR1, Sigmar1 and EBP (19 listed in DrugCentral).
• ATC code: C04AX28 (Other peripheral vasodilators).
• Molecular formula: C21H27NO2; molecular weight 325.45 g/mol.

Mechanism & targets

Molecular targets (19)

Target	Gene	Action	Activity
Translocator protein	Tspo	unknown	IC50 9.14
Sigma non-opioid intracellular receptor 1	SIGMAR1	unknown	Ki 8.99
Sigma non-opioid intracellular receptor 1	Sigmar1	unknown	Ki 8.70
3-beta-hydroxysteroid-delta(8),delta(7)-isomerase	EBP	unknown	Ki 8.57
Sigma non-opioid intracellular receptor 1	SIGMAR1	unknown	IC50 8.41
Glutamate NMDA receptor; GRIN1/GRIN2B	GRIN1|GRIN2B	unknown	Ki 8.00
Glutamate [NMDA] receptor subunit epsilon 2	Grin2b	unknown	Ki 7.96
Glutamate receptor ionotropic, NMDA 2B	GRIN2B	unknown	IC50 7.70
Glutamate receptor ionotropic, NMDA 1	Grin1	unknown	IC50 7.14
Sigma intracellular receptor 2	Tmem97	unknown	Ki 7.01
Potassium voltage-gated channel subfamily H member 2	KCNH2	unknown	IC50 7.00
Adrenergic receptor alpha-1	Adra1b|Adra1d|Adra1a	unknown	IC50 7.00
Alpha-2A adrenergic receptor	Adra2a	unknown	IC50 6.96
5-hydroxytryptamine receptor 1A	Htr1a	unknown	IC50 6.62
5-hydroxytryptamine receptor 2A	HTR2A	unknown	IC50 6.21
Histamine H1 receptor	HRH1	unknown	IC50 6.00
Glutamate receptor ionotropic, NMDA 2C	GRIN2C	unknown	IC50 4.54
Glutamate receptor ionotropic, NMDA 2A	GRIN2A	unknown	IC50 4.40
Glutamate receptor ionotropic, NMDA 2D	GRIN2D	unknown	IC50 4.12

ATC classification

ATC code	Therapeutic hierarchy
C04AX28	CARDIOVASCULAR SYSTEM › PERIPHERAL VASODILATORS › PERIPHERAL VASODILATORS › Other peripheral vasodilators

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Inappropriate antidiuretic hormone secretion	63.2

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Ifenprodil is on its molecule page.

• Molecular formula: C₂₁H₂₇NO₂
• Molecular weight: 325.45 g/mol
• CAS number: 23210-56-2
• InChIKey: UYNVMODNBIQBMV-UHFFFAOYSA-N
• PubChem CID: 3689

CC(C(O)C1=CC=C(O)C=C1)N1CCC(CC2=CC=CC=C2)CC1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Ifenprodil work?

Its molecular targets in DrugCentral include Tspo, SIGMAR1, Sigmar1 and EBP.

What is the chemical formula of Ifenprodil?

Ifenprodil has the molecular formula C21H27NO2 and a molecular weight of 325.45 g/mol.

Sources

• DrugCentral drug card 1419 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1886888 — compound record and bioactivity
• PubChem CID 3689 — chemical identifiers
• DrugBank DB08954 — drug record
• FDA UNII R8OE3P6O5S — substance identity
• UniProt Q99720 (SIGMAR1) — target protein
• UniProt Q13224 (GRIN2B) — target protein
• UniProt Q12809 (KCNH2) — target protein
• UniProt P35367 (HRH1) — target protein
• UniProt Q14957 (GRIN2C) — target protein
• UniProt Q12879 (GRIN2A) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.