Buflomedil
CARDIOVASCULAR SYSTEM
Also known as: buflomedil HCl, buflomedil hydrochloride
Data last refreshed: (DrugCentral release 2024-11-01)
Key facts
Buflomedil is a drug catalogued in DrugCentral. It was first approved by the YEAR INTRODUCED in 1976. DrugCentral lists 9 molecular targets, including EBP, SIGMAR1 and ERG2.
- Molecular targets: EBP, SIGMAR1, ERG2 and ADRA1D (9 listed in DrugCentral).
- ATC code: C04AX20 (Other peripheral vasodilators).
- Molecular formula: C17H25NO4; molecular weight 307.39 g/mol.
Mechanism & targets
Molecular targets (9)
| Target | Gene | Action | Activity |
|---|---|---|---|
| 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase | EBP | unknown | Ki 7.22 |
| Sigma non-opioid intracellular receptor 1 | SIGMAR1 | unknown | Ki 5.89 |
| C-8 sterol isomerase | ERG2 | unknown | Ki 5.15 |
| Alpha-1D adrenergic receptor | ADRA1D | unknown | — |
| Alpha-1B adrenergic receptor | ADRA1B | unknown | — |
| Voltage-dependent calcium channel gamma-1 subunit | CACNG1 | unknown | — |
| Alpha-2C adrenergic receptor | ADRA2C | unknown | — |
| Alpha-1A adrenergic receptor | ADRA1A | unknown | — |
| Alpha-2A adrenergic receptor | ADRA2A | unknown | — |
Regulatory approvals (1)
| Date | Agency | Marketed as | Applicant | Orphan |
|---|---|---|---|---|
| 1976-01-01 | YEAR INTRODUCED | — | — |
ATC classification
| ATC code | Therapeutic hierarchy |
|---|---|
C04AX20 | CARDIOVASCULAR SYSTEM › PERIPHERAL VASODILATORS › PERIPHERAL VASODILATORS › Other peripheral vasodilators |
Chemical structure
Full physicochemical, ADMET and 3D-structure analysis of Buflomedil is on its molecule page.
| Molecular formula | C17H25NO4 |
|---|---|
| Molecular weight | 307.39 g/mol |
| CAS number | 55837-25-7 |
| InChIKey | OWYLAEYXIQKAOL-UHFFFAOYSA-N |
| PubChem CID | 2467 |
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
How does Buflomedil work?
Its molecular targets in DrugCentral include EBP, SIGMAR1, ERG2 and ADRA1D.
When was Buflomedil first approved?
Buflomedil was first approved by the YEAR INTRODUCED in 1976.
What is the chemical formula of Buflomedil?
Buflomedil has the molecular formula C17H25NO4 and a molecular weight of 307.39 g/mol.
Browse: all drugs starting with B · drug guides by category · protein targets A–Z.
Sources
- DrugCentral drug card 422 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
- ChEMBL CHEMBL188921 — compound record and bioactivity
- PubChem CID 2467 — chemical identifiers
- DrugBank DB13510 — drug record
- FDA UNII V7I71DQ432 — substance identity
- UniProt Q15125 (EBP) — target protein
- UniProt Q99720 (SIGMAR1) — target protein
- UniProt P25100 (ADRA1D) — target protein
- UniProt P35368 (ADRA1B) — target protein
- UniProt Q06432 (CACNG1) — target protein
- UniProt P18825 (ADRA2C) — target protein
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.