Dyclonine

NERVOUS SYSTEM

Key facts

Dyclonine is an ofp drug catalogued in DrugCentral. DrugCentral lists 2 molecular targets, including ACHE and SCN10A. Recorded indications include Itching of skin, Local anesthesia, Minor Skin Wound Pain and Mouth Irritation.

• Approval status: ofp.
• Molecular targets: ACHE and SCN10A (2 listed in DrugCentral).
• Indications: Itching of skin, Local anesthesia, Minor Skin Wound Pain, Mouth Irritation and Prevent Minor Bacterial Skin Infection and others.
• ATC code: N01BX02 (Other local anesthetics).
• Molecular formula: C18H27NO2; molecular weight 289.42 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (7)

• Itching of skin
• Local anesthesia
• Minor Skin Wound Pain
• Mouth Irritation
• Prevent Minor Bacterial Skin Infection
• Skin irritation
• Suppression of the Gag Reflex

Contraindications (7)

• Bleeding hemorrhoids
• Conduction disorder of the heart
• Decreased respiratory function
• Denuded skin
• Disorder of mucous membrane
• Open wound
• Seizure disorder

Mechanism & targets

Molecular targets (2)

Target	Gene	Action	Activity
Acetylcholinesterase	ACHE	unknown	IC50 6.74
Sodium channel protein type 10 subunit alpha	SCN10A	blocker	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
—	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
N01BX02	NERVOUS SYSTEM › ANESTHETICS › ANESTHETICS, LOCAL › Other local anesthetics
R02AD04	RESPIRATORY SYSTEM › THROAT PREPARATIONS › THROAT PREPARATIONS › Anesthetics, local

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Heart rate abnormal	193.0
Blood magnesium decreased	152.9
Lymphadenitis	136.6
Muscle twitching	136.0
Soft tissue disorder	127.3
Infection	117.7
Clostridium difficile infection	115.9
Productive cough	105.4
Pneumonia viral	102.7
Thrombosis	83.1
Liver function test abnormal	79.3
White blood cell count decreased	76.8

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Dyclonine is on its molecule page.

• Molecular formula: C₁₈H₂₇NO₂
• Molecular weight: 289.42 g/mol
• CAS number: 586-60-7
• InChIKey: BZEWSEKUUPWQDQ-UHFFFAOYSA-N
• PubChem CID: 3180

CCCCOC1=CC=C(C=C1)C(=O)CCN1CCCCC1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Dyclonine used for?

DrugCentral lists the following indications for Dyclonine: Itching of skin, Local anesthesia, Minor Skin Wound Pain, Mouth Irritation, Prevent Minor Bacterial Skin Infection, Skin irritation and Suppression of the Gag Reflex.

How does Dyclonine work?

Its molecular targets in DrugCentral include ACHE and SCN10A (blocker).

What is the chemical formula of Dyclonine?

Dyclonine has the molecular formula C18H27NO2 and a molecular weight of 289.42 g/mol.

Sources

• DrugCentral drug card 974 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200478 — compound record and bioactivity
• PubChem CID 3180 — chemical identifiers
• DrugBank DB00645 — drug record
• FDA UNII 078A24Q30O — substance identity
• DailyMed: FDA labels for Dyclonine — current prescribing information (label search)
• UniProt P22303 (ACHE) — target protein
• UniProt Q9Y5Y9 (SCN10A) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.