Sodium channel protein type 10 subunit alpha (SCN10A)
Homo sapiens — UniProt Q9Y5Y9
Data last refreshed: (UniProt release unknown)
Key facts
Sodium channel protein type 10 subunit alpha (SCN10A) is a protein from Homo sapiens identified by UniProt accession Q9Y5Y9, 1956 residues long. MolForge cross-references it against 14 known binders and 524 disease associations.
- UniProt accession: Q9Y5Y9; gene symbol SCN10A.
- Organism: Homo sapiens.
- Length: 1956 amino acids.
- Approved drugs acting on it (DrugCentral): Suzetrigine, Orphenadrine, Mexiletine, Lamotrigine and Benzocaine and others.
- Top disease associations (Open Targets): atrial fibrillation, episodic pain syndrome, familial, 2 and epilepsy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sodium channel protein type 10 subunit alpha |
|---|---|
| UniProt accession | Q9Y5Y9 |
| Gene | SCN10A |
| Organism | Homo sapiens |
| Length | 1956 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (13)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (524)
Diseases linked to this target (Open Targets).
- atrial fibrillation · score 0.72
- episodic pain syndrome, familial, 2 · score 0.67
- epilepsy · score 0.61
- pain · score 0.61
- migraine disorder · score 0.61
- bipolar disorder · score 0.61
- Seizure · score 0.60
- partial epilepsy · score 0.60
- unipolar depression · score 0.60
- Pruritus · score 0.59
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5Y9-F1 | alphafold | PREDICTED | 67.30 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5Y9.
Amino-acid sequence (1956 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target SCN10A?
DrugCentral lists 13 approved drugs whose mechanism of action is SCN10A: Suzetrigine, Orphenadrine, Mexiletine, Lamotrigine, Benzocaine, Chloroprocaine, Cinchocaine and Dyclonine and others.
Which diseases are associated with SCN10A?
The strongest Open Targets associations for SCN10A are atrial fibrillation, episodic pain syndrome, familial, 2, epilepsy, pain and migraine disorder.
How long is the SCN10A protein?
The Homo sapiens SCN10A protein (UniProt Q9Y5Y9) is 1956 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5Y9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5Y9 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.