Cinchocaine

Standardized Chemical Allergen — CARDIOVASCULAR SYSTEM

Key facts

Cinchocaine is an ofm drug in the Standardized Chemical Allergen class catalogued in DrugCentral. DrugCentral lists 3 molecular targets, including SCN1A|SCN2A|SCN3A, SCN5A and SCN10A. Recorded indications include Itching of skin, Minor Skin Wound Pain and Skin irritation.

• Approval status: ofm.
• Drug class: Standardized Chemical Allergen.
• Molecular targets: SCN1A|SCN2A|SCN3A, SCN5A and SCN10A (3 listed in DrugCentral).
• Indications: Itching of skin, Minor Skin Wound Pain and Skin irritation.
• ATC code: C05AD04 (Local anesthetics).
• Molecular formula: C20H29N3O2; molecular weight 343.47 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (3)

• Itching of skin
• Minor Skin Wound Pain
• Skin irritation

Contraindications (12)

• Bleeding hemorrhoids
• Conduction disorder of the heart
• Decreased respiratory function
• Deficiency of cholinesterase
• Denuded skin
• Disease of liver
• Disorder of cardiovascular system
• Disorder of mucous membrane
• Kidney disease
• Myasthenia gravis
• Open wound
• Seizure disorder

Mechanism & targets

• Established pharmacologic class: Standardized Chemical Allergen

Molecular targets (3)

Target	Gene	Action	Activity
Sodium channel alpha subunits; brain (Types I, II, III)	SCN1A|SCN2A|SCN3A	unknown	IC50 5.85
Sodium channel protein type 5 subunit alpha	SCN5A	blocker	—
Sodium channel protein type 10 subunit alpha	SCN10A	blocker	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
—	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
C05AD04	CARDIOVASCULAR SYSTEM › VASOPROTECTIVES › AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE › Local anesthetics
D04AB02	DERMATOLOGICALS › ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. › ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. › Anesthetics for topical use
N01BB06	NERVOUS SYSTEM › ANESTHETICS › ANESTHETICS, LOCAL › Amides
S01HA06	SENSORY ORGANS › OPHTHALMOLOGICALS › LOCAL ANESTHETICS › Local anesthetics
S02DA04	SENSORY ORGANS › OTOLOGICALS › OTHER OTOLOGICALS › Analgesics and anesthetics

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Heart sounds	125.7
Prolonged expiration	118.8
Depressive symptom	84.8
Respiration abnormal	80.8
Appetite disorder	80.7
Flank pain	65.8
Rales	65.3

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Cinchocaine is on its molecule page.

• Molecular formula: C₂₀H₂₉N₃O₂
• Molecular weight: 343.47 g/mol
• CAS number: 85-79-0
• InChIKey: PUFQVTATUTYEAL-UHFFFAOYSA-N
• PubChem CID: 3025

CCCCOC1=NC2=CC=CC=C2C(=C1)C(=O)NCCN(CC)CC

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Cinchocaine used for?

DrugCentral lists the following indications for Cinchocaine: Itching of skin, Minor Skin Wound Pain and Skin irritation.

How does Cinchocaine work?

Its molecular targets in DrugCentral include SCN1A|SCN2A|SCN3A, SCN5A (blocker) and SCN10A (blocker).

What drug class does Cinchocaine belong to?

Cinchocaine is in the Standardized Chemical Allergen class.

What is the chemical formula of Cinchocaine?

Cinchocaine has the molecular formula C20H29N3O2 and a molecular weight of 343.47 g/mol.

Sources

• DrugCentral drug card 859 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1086 — compound record and bioactivity
• PubChem CID 3025 — chemical identifiers
• DrugBank DB00527 — drug record
• FDA UNII L6JW2TJG99 — substance identity
• DailyMed: FDA labels for Cinchocaine — current prescribing information (label search)
• UniProt Q14524 (SCN5A) — target protein
• UniProt Q9Y5Y9 (SCN10A) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.