Pipamperone

NERVOUS SYSTEM

Key facts

Pipamperone is a drug catalogued in DrugCentral. DrugCentral lists 16 molecular targets, including HTR2A, ADRA2B and HTR2B.

• Molecular targets: HTR2A, ADRA2B, HTR2B and DRD2 (16 listed in DrugCentral).
• ATC code: N05AD05 (Butyrophenone derivatives).
• Molecular formula: C21H30FN3O2; molecular weight 375.49 g/mol.

Mechanism & targets

Molecular targets (16)

Target	Gene	Action	Activity
5-hydroxytryptamine receptor 2A	HTR2A	antagonist	Ki 8.30
Alpha-2B adrenergic receptor	ADRA2B	unknown	Ki 7.46
5-hydroxytryptamine receptor 2B	HTR2B	unknown	Ki 7.32
D(2) dopamine receptor	DRD2	unknown	Ki 6.94
5-hydroxytryptamine receptor 1D	HTR1D	antagonist	Ki 6.80
5-hydroxytryptamine receptor 2C	HTR2C	unknown	Ki 6.64
D(3) dopamine receptor	DRD3	unknown	Ki 6.60
Alpha-2C adrenergic receptor	ADRA2C	unknown	Ki 6.54
5-hydroxytryptamine receptor 1B	HTR1B	antagonist	Ki 6.20
Alpha-2A adrenergic receptor	ADRA2A	unknown	Ki 6.07
5-hydroxytryptamine receptor 1A	HTR1A	antagonist	Ki 5.60
Histamine H1 receptor	HRH1	antagonist	Ki 5.60
Beta-1 adrenergic receptor	ADRB1	unknown	Ki 5.30
Beta-2 adrenergic receptor	ADRB2	unknown	Ki 5.30
5-hydroxytryptamine receptor 1F	HTR1F	unknown	Ki 5.30
5-hydroxytryptamine receptor 1E	HTR1E	unknown	Ki 5.30

ATC classification

ATC code	Therapeutic hierarchy
N05AD05	NERVOUS SYSTEM › PSYCHOLEPTICS › ANTIPSYCHOTICS › Butyrophenone derivatives

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Brain scan abnormal	190.1
Cerebral artery thrombosis	188.3
General physical health deterioration	170.5
Fall	153.1
Product prescribing error	149.9
Areflexia	141.4
Restlessness	134.1
Drug interaction	133.6
Paroxysmal perceptual alteration	127.7
Product monitoring error	119.7
Labelled drug-drug interaction medication error	111.2
Electrocardiogram QT prolonged	110.2

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Pipamperone is on its molecule page.

• Molecular formula: C₂₁H₃₀FN₃O₂
• Molecular weight: 375.49 g/mol
• CAS number: 1893-33-0
• InChIKey: AXKPFOAXAHJUAG-UHFFFAOYSA-N
• PubChem CID: 4830

NC(=O)C1(CCN(CCCC(=O)C2=CC=C(F)C=C2)CC1)N1CCCCC1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Pipamperone work?

Its molecular targets in DrugCentral include HTR2A (antagonist), ADRA2B, HTR2B and DRD2.

What is the chemical formula of Pipamperone?

Pipamperone has the molecular formula C21H30FN3O2 and a molecular weight of 375.49 g/mol.

Sources

• DrugCentral drug card 2181 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL440294 — compound record and bioactivity
• PubChem CID 4830 — chemical identifiers
• DrugBank DB09286 — drug record
• FDA UNII 5402501F0W — substance identity
• UniProt P28223 (HTR2A) — target protein
• UniProt P18089 (ADRA2B) — target protein
• UniProt P41595 (HTR2B) — target protein
• UniProt P14416 (DRD2) — target protein
• UniProt P28221 (HTR1D) — target protein
• UniProt P28335 (HTR2C) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.