Benperidol

NERVOUS SYSTEM

Key facts

Benperidol is a drug catalogued in DrugCentral. It was first approved by the YEAR INTRODUCED in 1965. DrugCentral lists 6 molecular targets, including DRD2, DRD3 and HTR2A. Recorded indications include Antisocial behavior.

• Molecular targets: DRD2, DRD3, HTR2A and DRD4 (6 listed in DrugCentral).
• Indications: Antisocial behavior.
• ATC code: N05AD07 (Butyrophenone derivatives).
• Molecular formula: C22H24FN3O2; molecular weight 381.45 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Antisocial behavior

Mechanism & targets

Molecular targets (6)

Target	Gene	Action	Activity
D(2) dopamine receptor	DRD2	unknown	Ki 10.57
D(3) dopamine receptor	DRD3	unknown	Ki 10.18
5-hydroxytryptamine receptor 2A	HTR2A	unknown	Ki 9.00
D(4) dopamine receptor	DRD4	unknown	Ki 8.70
Potassium voltage-gated channel subfamily H member 2	KCNH2	unknown	IC50 8.47
Sigma non-opioid intracellular receptor 1	SIGMAR1	unknown	EC50 5.94

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1965-01-01	YEAR INTRODUCED	—	—

ATC classification

ATC code	Therapeutic hierarchy
N05AD07	NERVOUS SYSTEM › PSYCHOLEPTICS › ANTIPSYCHOTICS › Butyrophenone derivatives

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Neuroleptic malignant syndrome	162.1
Psychotic symptom	101.8

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Benperidol is on its molecule page.

• Molecular formula: C₂₂H₂₄FN₃O₂
• Molecular weight: 381.45 g/mol
• CAS number: 2062-84-2
• InChIKey: FEBOTPHFXYHVPL-UHFFFAOYSA-N
• PubChem CID: 16363

FC1=CC=C(C=C1)C(=O)CCCN1CCC(CC1)N1C(=O)NC2=C1C=CC=C2

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Benperidol used for?

DrugCentral lists the following indications for Benperidol: Antisocial behavior.

How does Benperidol work?

Its molecular targets in DrugCentral include DRD2, DRD3, HTR2A and DRD4.

When was Benperidol first approved?

Benperidol was first approved by the YEAR INTRODUCED in 1965.

What is the chemical formula of Benperidol?

Benperidol has the molecular formula C22H24FN3O2 and a molecular weight of 381.45 g/mol.

Sources

• DrugCentral drug card 312 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL297302 — compound record and bioactivity
• PubChem CID 16363 — chemical identifiers
• DrugBank DB12867 — drug record
• FDA UNII 97O6X78C53 — substance identity
• UniProt P14416 (DRD2) — target protein
• UniProt P35462 (DRD3) — target protein
• UniProt P28223 (HTR2A) — target protein
• UniProt P21917 (DRD4) — target protein
• UniProt Q12809 (KCNH2) — target protein
• UniProt Q99720 (SIGMAR1) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.